TetR family transcriptional regulators: Lipid metabolism and drug resistance in mycobacteria

Singh, Parul; Jain, Ankush; Chhabra, Ravindresh; Kaur, Jagdeep

doi:10.1016/j.genrep.2024.101938

Gene Reports

2024

DOI: 10.1016/j.genrep.2024.101938

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TetR family transcriptional regulators: Lipid metabolism and drug resistance in mycobacteria

Parul Singh,

Ankush Jain,

Ravindresh Chhabra

et al.

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2024

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Cited by 1 publication

References 135 publications

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Embleporicin: A Novel Class I Lanthipeptide from the Actinobacteria Embleya sp. NF3

Roblero-Mejía,

García-Ausencio,

Rodríguez-Sanoja

et al. 2024

Antibiotics

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Genome mining has emerged as a revolutionary tool for discovering new ribosomally synthesized and post-translationally modified peptides (RiPPs) in various genomes. Recently, these approaches have been used to detect and explore unique environments as sources of RiPP-producing microorganisms, particularly focusing on endophytic microorganisms found in medicinal plants. Some endophytic actinobacteria, especially strains of Streptomyces, are notable examples of peptide producers, as specific biosynthetic clusters encode them. To uncover the genetic potential of these organisms, we analyzed the genome of the endophytic actinobacterium Embleya sp. NF3 using genome mining and bioinformatics tools. Our analysis led to the identification of a putative class I lanthipeptide. We cloned the core biosynthetic genes of this putative lanthipeptide, named embleporicin, and expressed them in vitro using a cell-free protein system (CFPS). The resulting product demonstrated antimicrobial activity against Micrococcus luteus ATCC 9341. This represents the first RiPP reported in the genus Embleya and the first actinobacterial lanthipeptide produced through cell-free technology.

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Embleporicin: A Novel Class I Lanthipeptide from the Actinobacteria Embleya sp. NF3

Roblero-Mejía,

García-Ausencio,

Rodríguez-Sanoja

et al. 2024

Antibiotics

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TetR family transcriptional regulators: Lipid metabolism and drug resistance in mycobacteria

Cited by 1 publication

References 135 publications

Embleporicin: A Novel Class I Lanthipeptide from the Actinobacteria Embleya sp. NF3

Embleporicin: A Novel Class I Lanthipeptide from the Actinobacteria Embleya sp. NF3

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