Tetrabutyl ammonium bromide-mediated benzylation of phenols in water under mild condition

A Ligand‐Enabled Palladium‐Catalyzed Highly para‐Selective Difluoromethylation of Aromatic Ketones

“…Fluorine-containing functional groups usually improve the bioactivity of drugs.Hence,directly introducing fluorinecontaining functional groups into natural bioactive compounds could accelerate the development of new drugs.O ur method was successfully applied to the late-stage functionalization of several well-known drugs,s uch as ketoprofen, zaltoprofen, oxybenzone,a nd chrysazin to yield the corresponding products (8a-d)i nm oderate to good yields,a nd with recovery of the unreacted starting materials (Scheme 1). Ad ifluoromethylated propafenone key precursor [19] 8e was also obtained in moderate yield. Subsequently,w ee xplored the transformation of these difluoromethylated bioactive compounds.F or example,t he benzyl group of the di-fluoromethylated product (8c)c ould be removed under ak nown reaction procedure in excellent yield (9a).…”

“…Our method was successfully applied to the late‐stage functionalization of several well‐known drugs, such as ketoprofen, zaltoprofen, oxybenzone, and chrysazin to yield the corresponding products ( 8 a – d ) in moderate to good yields, and with recovery of the unreacted starting materials (Scheme ). A difluoromethylated propafenone key precursor 8 e was also obtained in moderate yield. Subsequently, we explored the transformation of these difluoromethylated bioactive compounds.…”

A Ligand‐Enabled Palladium‐Catalyzed Highly para‐Selective Difluoromethylation of Aromatic Ketones

“…Ad ifluoromethylated propafenone key precursor [19] 8e was also obtained in moderate yield. Ad ifluoromethylated propafenone key precursor [19] 8e was also obtained in moderate yield.…”

Synthesis and Biological Evaluation of New Eugenol-Derived 1,2,3-Triazoles as Antimycobacterial Agents

“…The ethers TS12-TS17 were synthesized in polar solvents with tetrabutylammonium bromide (TBAB, yields 37-61%). 37 In their IR spectra, C-O stretch from methoxyl/ ether group is related to bands at 1263-1223 cm -1 . Singlets at d 5.18, 5.07, 5.08 and 5.12 ppm are associated with the benzylic hydrogens as expected.…”