Tetracyclic Triterpenoids of the Fruit Coats of Azadirachta indica

Siddiqui, Salimuzzaman; Siddiqui, Bina Shaheen; Ghiasuddin,; Faizi, Shaheen

doi:10.1021/np50074a010

Cited by 25 publications

(15 citation statements)

References 15 publications

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“…Presence of mahmoodin, azadirachtol, and naheedin in oil and fruit coat of the tree was established using 2D NMR and chemical analysis (Siddiqui et al, 1992). Later on, examination of fruit coat using spectroscopic techniques revealed the presence of new tetracyclic triterpenoids such as salimuzzalin, azadirolic acid, azadiradinol, and azadironol (Siddiqui et al, 1998). Previously, same group has confirmed the structures oflimocinone, limocin A, limocin B, limocinol, limocinin (Siddiqui et al, 1991), isonimolicinolide, and nimolicinoic acid (Siddiqui, Mahmood, Faizi, & Siddiqui, 1987) from uncrushed ripened A recent study showed that fresh fruit contained azadirone, epoxyazadiradione, and azadiradione (Haldar, Phapale, Kolet, & Thulasiram, 2013).…”

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confidence: 99%

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

128

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Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A. indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.

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confidence: 99%

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

128

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“…8, 137.6 (C-20). The appearance of double signal for these carbon indicated 4 to be an epimeric mixture at C-23 (10).…”

Section: Resultsmentioning

confidence: 99%

Photooxidation of Cedrelone, a Tetranortriterpenoid from Toona ciliata¶

Gopalakrishnan¹,

Singh²,

Kasinath³

et al. 2000

Photochem Photobiol

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Cedrelone, a tetranortriterpenoid on photolysis by UV light yields a true photooxidation product 3 [14 beta,15beta,22beta,23beta-diepoxy-6-hydroxy-1,5, 20(22)-meliatriene-2,7,21-trione] whose structure is well established by NMR studies and confirmed by X-ray crystallography, along with product 4 [14 beta,15beta-epoxy-6,23-dihydroxy-1,5,20(22)-meliatriene-2,7, 21-trione]. Addition of rose bengal increases the rate of photooxidation whereas DABCO decreases rate of photolysis proving the involvement of singlet oxygen in the photooxygenation. Both the photoproducts exhibited antifeedant activity.

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“…However, a three-generation study in male and female rats fed a diet containing Azadirachta indica debitterised oil did not show any adverse effects on general health or reproductive parameters (Chinnasamy et al, 1993). The structures of more than 100 constituents of Azadirachta indica have been elucidated (Siddiqui et al, 1988;Van der Nat et al, 1991;Siddiqui et al, 1998;Luo et al, 2000) and some have been tested for their effects on mammals. These include azadirachtin, the best documented pure compound, and nimbidin.…”

Section: Discussionmentioning

confidence: 99%