Tetracycline (Achromycin)-Neomycin for Preoperative Colon Preparation

Cohn, Isidore; Longacre, Alfred B.

doi:10.1001/archsurg.1956.01270210001001

Cited by 18 publications

(3 citation statements)

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“…Starting with sulfathalidine [ 18 ], various antibiotic therapies have been studied, such as neomycin alone or a combination of neomycin and tetracycline. However, tetracycline was prohibited due to the occurrence of resistance [ 19 ]. Instead of these drugs, the combination of kanamycin and MBP was recommended to prevent SSI [ 20 ].…”

Section: History Of Bowel Preparationmentioning

confidence: 99%

A Review of Bowel Preparation Before Colorectal Surgery

Min

2021

Ann Coloproctol

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Some patients who have undergone preoperative chemoradiotherapy (CRT) following surgery have been diagnosed with late recurrence more than 5 years after treatment, raising questions about the possible benefit extending surveillance beyond the recommended 5 years. In 2011, a 71-year-old male was diagnosed with T3N+ low-lying rectal cancer located 3 cm from the anal verge before undergoing long-course preoperative CRT. After CRT, the patient was reexamined and diagnosed with ycT1-2N0 lesion, so local excision(LE) was performed. The patient underwent intensive surveillance for up to 5 years, and no evidence of recurrence was found. At 74 months after surgery, the patient was hospitalized for a hematochezia, and local recurrence at the excision site and peritoneal seeding nodules were identified. Considering the late recurrence in this patient, it might be necessary to long-term follow-up beyond 5 years in patients with preoperative CRT followed by LE.

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Section: History Of Bowel Preparationmentioning

confidence: 99%

A Review of Bowel Preparation Before Colorectal Surgery

Min

2021

Ann Coloproctol

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“…The results so far do not indicate how long such antibiotic-resistant flora remain in the gut of these patients. An additional danger in cancer surgery is the increased risk of implantation of tumour at the anastomosis when the bowel has been rendered relatively free of microorganisms (Vink, 1954;Cohn, andAtik, 1960, 1961). We are well aware of the dangers of tumour dissemination, and suitable precautions, both technical and involving the use of antimitotic drugs, have been used for eight years.…”

Section: Discussionmentioning

confidence: 99%

“…In a controlled study, one of the authors showed that the incidence of infection following resection of the colon was 40% in two groups of patients, one receiving sulphonamide pre-operatively, also post-operative intramuscular penicillin and streptomycin, and the other receiving no antibiotics. Neomycin has also been widely used and large doses of several grams per day have been used over a short period of time, although pharmacological toxicity is fairly common (Cohn and Atik, 1961;Fog, 1954). In an experimental study using rats the most effective method of controlling infection following colon anastomosis was to give the drug (neomycin) orally before operation and into the lumen post-operatively (Gunn, Ch.M.…”

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confidence: 99%