Tetracycline and Demethylchlortetracycline in Man

Kunin, Calvin M.

doi:10.1001/archinte.1962.03620200026006

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…We assessed the value of measuring Escherichia coli antibodies in patients -with suspected immunodeficiency disease by comparison with a normal adult population and a number of patients with hypoganmnaglobulinaemia. Natural antibodies to the 0 antigen of coumnensal E. coli spontaneously occur in the serum of all normal children and remain throughout adult life (Kunin, 1962). These antibodies are presumably stimulated by E. coli bacteria in the gut.…”

Section: Introductionmentioning

confidence: 99%

Escherichia coli Antibody: A Screening Test for Immunodeficiency

Webster¹,

Efter²,

Asherson³

1974

BMJ

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Six patients suffering from recurrent chest infections were found to lack antibodies to a pooled antigen obtained from six different serotypes of commensal Escherichia coli bacteria. All had normal serum IgG concentrations, but five subsequently benefited from regular gammaglobulin injections. We suggest that the absence of such E. coli antibodies usually indicates a clinically significant defect in antibody production. This simple screening test is of use in the diagnosis of primary and secondary immunodeficiency disorders.

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Section: Introductionmentioning

confidence: 99%

Escherichia coli Antibody: A Screening Test for Immunodeficiency

Webster¹,

Efter²,

Asherson³

1974

BMJ

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“…It is active against a wide range of Gram-positive and Gramnegative organisms, and is said to be more active against some organisms than tetracycline both in vitro and in vivo (Te-wen Chang and Weinstein, 1962). In vivo studies by Kunin (1962) suggest that at least, in part, this effect may be due to delayed renal excretion.…”

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confidence: 99%