Tetracycline Conditioning Augments the In Vivo Inflammatory Response Induced by Cementum Extracts

Abstract

The present results demonstrate that conditioning of diseased cementum with tetracycline may induce an intense inflammatory response in a mouse model, and they suggest that local application of tetracycline for root conditioning should be carefully reinvestigated.

Introduction of polyvinyl pyrrolidone (PVP) In the non surgical periotherapy of Rapidly progressive periodontitis

“…The bactericidal effect of antiseptics or antibiotics when used as subgingival irrigations seemed to be unable to act on the bottom of deep pockets, it seemed to need a long duration exposure with bacteria or a higher concentration was suggested (9,69,74) taking in consideration the increased tissulor damages associated with augmented concentration (57,62) . Conditioning the diseased cementum with tetracycline may induce an intense inflammatory response (88) . The bactericidal action of systemic antibiotics seemed to be week, it could enhanced when accompanied with scaling and root planning, but its duration still shortly effective (6,17,30,69,70) .…”

“…The bactericidal action of systemic antibiotics seemed to be week, it could enhanced when accompanied with scaling and root planning, but its duration still shortly effective (6,17,30,69,70) . Tetracycline, Doxycycline and Minocycline (17,70) showed 4-8 μl/ml concentration in the gingival fluid after 24h when 1 gram/day have been taken (88) this concentration is effective bactericidal when associated with conventional scaling and root planning, it appeared useless when administered alone (44,53) . The complex bacterial flora of RPP pockets could need highly effective bactericidal subgingival irrigating solution, with save topical use, or at least 10 different antibiotic regimens might be required to specifically target the various pathogen complex (6) .…”