Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier

Bottino, Marco C.; Münchow, Eliseu A.; Albuquerque, Maria Tereza Pedrosa de; Kamocki, Krzysztof; Shahi, Rana; Gregory, Richard L.; Chu, Tien Min G.; Pankajakshan, Divya

doi:10.1002/jbm.b.33743

Cited by 36 publications

(31 citation statements)

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“…Our ongoing research focuses on synthesizing antibiotic-containing nanofibers on titanium dental implants [33] to first study in vitro the antimicrobial properties against a multispecies peri-implantitis-relevant biofilm, and later to evaluate its effects on a pre-clinical animal model. Taken together, this study demonstrated that antibiotic-containing fibers can effectively inhibit peri-implantitis-related biofilm formation, suggesting that tetracycline fibers hold great potential as an antibacterial implant coating.…”

Section: Resultsmentioning

confidence: 99%

Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating

et al. 2016

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The purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Prevotella intermedia (Pi), and Aggregatibacter actinomycetemcomitans (Aa)]. Tetracycline hydrochloride (TCH) was added to a poly(DL-lactide) [PLA], poly(ε-caprolactone) [PCL], and gelatin [GEL] polymer blend solution at distinct concentrations to obtain the following fibers: PLA:PCL/GEL (TCH-free, control), PLA:PCL/GEL+5%TCH, PLA:PCL/GEL+10%TCH, and PLA:PCL/GEL+25%TCH. The inhibitory effect of TCH-containing fibers on biofilm formation was assessed by colony-forming units (CFU/mL). Qualitative analysis of biofilm inhibition was done via scanning electron microscopy (SEM). Statistical significance was reported at p<0.05. Complete inhibition of biofilm formation on the fibers was observed in groups containing TCH at 10 and 25 wt.%. Fibers containing TCH at 5 wt.% demonstrated complete inhibition of Aa biofilm. Even though a marked reduction in CFU/mL was observed with an increase in TCH concentration, Pi proved to be the most resilient microorganism. SEM images revealed the absence of or a notable decrease in bacterial biofilm on the TCH-containing nanofibers. Collectively, our data suggests that tetracycline-containing fibers hold great potential as an antibacterial dental implant coating.

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Section: Resultsmentioning

confidence: 99%

Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating

et al. 2016

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“…Application Oral Diseases Composition micro/nano particles micro/nano sphere dental caries [31,35] periodontitis [38] implant coating [50,51] oral candidiasis [52] PLGA, PDLLA, PEG and biopolymers like lipid, chitosan, pectin, and alginate nanofiber periodontitis [19] oral candidiasis [53] implant coating [43] nano capsule dental resin modification [42] hydrogel dental caries [54] periodontitis [55,56] oral candidiasis [57] Hydrophilic groups such as -OH, -CONH-, -CONH2dendrimer dental caries [58] PAMAM, poly(aryl ether) Figure 1. Examples of the structures of different kinds of carriers.…”

Section: Types Of Carriersmentioning

confidence: 99%

“…For example, some nanoparticles and nano capsules have been added to dental resin for caries prevention loaded with anti-bacterial agents while nanofibers can be coating on dental implants as since they could act as a scaffold for tissue regeneration. Recently, research has also reported pH-responsive nanoparticles that could respond to the acidic oral environment [42,43]. The nanoparticles modified with pH-sensitive groups such as tertiary amine showed structural changes in acid, thus leading to trigged drug release [47].…”

Section: Micro/nanoparticlesmentioning

confidence: 99%

“…A. Besinis et al reported a dual layered nanocoating comprising silver, titanium dioxide, and hydroxyapatite [174]. Bottino et al fabricated a gelatin nanofiber loaded with tetracycline, which demonstrated great anti-bacterial effect and induced the growth of osteo-precursor cells [43]. Furthermore, researchers found out paramagnetic implants can promote the osteogenic response of pre-osteoblast cells.…”

Section: Dds For Peri-implantitismentioning

confidence: 99%

“…The carriers could be designed and modified for the loading of anti-bacterial agents [35][36][37], anti-inflammatory drugs [38], and biomolecules like protein and gene, growth factors, which expanded the application of DDS in oral diseases [39][40][41]. These nano-scaled DDS are combined with dental materials like dental restoration systems and dental implants for anti-bacterial modification without affecting their basic properties [42,43]. Further, hydrogel DDS with great biocompatibility and high drug-loading rate have also been applied in oral diseases, especially in periodontal diseases.…”

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confidence: 99%

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Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Implants

2018

Materials, Chemicals and Methods for Dental Applications

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Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier

Cited by 36 publications

References 27 publications

Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating

Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

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