Tetracycline-incorporated Silk Fibroin Films

Kim, Jong Ho; Shin, Bong Seob; Jeon, Jong Young; Kweon, HaeYong; Jo, You Young; Lee, Heui Sam; Lee, Kwang Gill

doi:10.7852/ijie.2012.25.1.129

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Silkworm produced material (SM) has been widely used as surgical suture and textile fiber for many centuries [ 4 ]. SM has many properties suitable for wound dressing: biocompatibility, minimal inflammatory reaction, capability to promote wound healing, strength, toughness, light weight, and easy chemical modification [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Powdered Wound Dressing Materials Made from wild Silkworm Antheraea pernyi Silk Fibroin on Full-skin Thickness Burn Wounds on Rats

Kim

Yoo

Kwon

et al. 2014

Maxillofacial Plastic and Reconstructive Surgery

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Purpose:This study evaluated powdered burn wound dressing materials from wild silkworm fibroin in an animal model.Methods:Fifteen rats were used in this experiment. Full-thickness 2×2 cm burn wounds were created on the back of rats under anesthesia. In the two experimental groups, the wounds were treated with two different dressing materials made from silkworm fibroin. In the Control Group, natural healing without any dressing material was set as control. The wound surface area was measured at five days, seven days and 14 days. Wound healing was evaluated by histologic analysis.Results:By gross observation, there were no infections or severe inflammations through 14 days post-injury. The differences among groups were statistically significant at seven days and 14 days, postoperatively (P <0.037 and 0.001, respectively). By post hoc test, the defect size was significantly smaller in experimental Group 1 compared with the Control Group and experimental Group 2 at seven days postoperatively (P =0.022 and 0.029, respectively). The difference between Group 1 and Group 2 was statistically significant at 14 days postoperatively (P <0.001). Group 1 and control also differed significantly (P =0.002). Group 1 showed a smaller residual scar than the Control Group and Group 2 at 14 days post-injury. Histologic analysis showed more re-epithelization in Groups 1 and 2 than in the Control Groups.Conclusion:Burn wound healing was accelerated with silk fibroin spun by wild silkworm Antheraea pernyi. There was no atypical inflammation with silk dressing materials. In conclusion, silk dressing materials can be used for treatment of burn wound.

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Section: Introductionmentioning

confidence: 99%