Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

Kim, Da Sol; Ko, Byoung‐Seob; Ryuk, Jin Ah; Park, Sunmin

doi:10.3390/ijms21082900

Cited by 22 publications

(27 citation statements)

References 35 publications

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“…Tetragonia tetragonioides Kuntze (TTK) extract was also shown to protect against short-term and special memory loss, which might involve the upregulation of the hippocampal pCREB/pAk/pGSK-3β pathway, expression of BDNF and CNTF, and cytokines such as TNF-α and IL-1β. These changes were accompanied by a decrease in Clostridiales , Erysipelotrichales , and Desulfovibrionales but an increase in Lactobacillales and Bacteroidales ( Kim et al, 2020 ). Such cognition-improving effects were seen in Tibetan fermented milk-treated APP/PS1 AD mice, which showed an increase in intestinal microbial diversity and increased abundance of Bacteroides, Faecalibacterium spp.…”

Section: Alterations In the Gut Microbiota Affect Hippocampus-dependementioning

confidence: 99%

“…Additionally, as mentioned above, the administration of TTK extract and Tibetan fermented milk also improved memory loss and reduced the deposition of hippocampal Aβ that involved changes in gut Clostridiales , Erysipelotrichales , Desulfovibrionales , Lactobacillales , Bacteroides , Faecalibacterium spp. Mucispirillum, and Ruminiclostridium ( Kim et al, 2020 ; Liu et al, 2020 ). Additionally, mice treated with a ketogenic diet for 16 weeks showed significantly increased abundance of putatively beneficial gut microbiota ( Akkermansia muciniphila and Lactobacillus ), and reduced putatively proinflammatory taxa ( Desulfovibrio and Turicibacter ).…”

Section: Gut Microbiota and Hippocampal Alzheimer’s Disease Pathologimentioning

confidence: 99%

“…decrease in Clostridiales, Erysipelotrichales, and Desulfovibrionales but increase in Lactobacilales and Bacteroidales short-term and special memory(Kim et al, 2020) Tibetan fermented milk Bacteroides, Faecalibacterium spp. Mucispirillum, Ruminiclostridium; Muribaculum, Erysipelatoclostridium cognitive function(Liu et al, 2020) LW-AFC: an herbal medicine prepared from traditional Chinese medicine from LiuweiDihuang decoction.…”

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confidence: 93%

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Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Tang

Meng

et al. 2021

Front. Cell. Infect. Microbiol.

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The study of the gut microbiota-brain axis has become an intriguing field, attracting attention from both gastroenterologists and neurobiologists. The hippocampus is the center of learning and memory, and plays a pivotal role in neurodegenerative diseases, such as Alzheimer’s disease (AD). Previous studies using diet administration, antibiotics, probiotics, prebiotics, germ-free mice, and fecal analysis of normal and specific pathogen-free animals have shown that the structure and function of the hippocampus are affected by the gut microbiota. Furthermore, hippocampal pathologies in AD are positively correlated with changes in specific microbiota. Genomic and neurochemical analyses revealed significant alterations in genes and amino acids in the hippocampus of AD subjects following a remarkable shift in the gut microbiota. In a recent study, when young animals were transplanted with fecal microbiota derived from AD patients, the recipients showed significant impairment of cognitive behaviors, AD pathologies, and changes in neuronal plasticity and cytokines. Other studies have demonstrated the side effects of antibiotic administration along with the beneficial effects of probiotics, prebiotics, and specific diets on the composition of the gut microbiota and hippocampal functions, but these have been mostly preliminary with unclear mechanisms. Since some specific gut bacteria are positively or negatively correlated to the structure and function of the hippocampus, it is expected that specific gut bacteria administration and other microbiota-based interventions could be potentially applied to prevent or treat hippocampus-based memory impairment and neuropsychiatric disorders such as AD.

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Section: Alterations In the Gut Microbiota Affect Hippocampus-dependementioning

confidence: 99%

Section: Gut Microbiota and Hippocampal Alzheimer’s Disease Pathologimentioning

confidence: 99%

mentioning

confidence: 93%

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Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Tang

Meng

et al. 2021

Front. Cell. Infect. Microbiol.

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“…The amount of protein in the supernatant was measured using the Bio-Rad protein assay kit (Bio-Rad, Hercules, CA, USA). The lysates having protein (30-50 µg) were resolved into sodium dodecyl sulfatepolyacrylamide gel electrophoresis as described in the previous study [57]. The amount of the interested protein was examined with the specific antibodies as follows: protein kinase B (PKB or Akt), phosphorylated PKB Ser473 , glycogen synthase kinase (GSK)-3β, and phosphorylated GSK-3β ser9 .…”

Section: Histopathological Analysismentioning

confidence: 99%

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

Zhang

Cao

et al. 2021

Pharmaceuticals

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Paeonia lactiflora Pallas (PL) and Poria cocos Wolf (PC) have been traditionally used to treat inflammatory diseases reported in Dongui Bogam and Shen Nong Ben Cao Jing, traditional medical books in Korean and China, respectively. We determined the efficacies and the molecular mechanisms of PL, PC, and PL + PC aqueous extracts on androgenetic alopecia (AGA) induced by testosterone propionate in C57BL/6 mice. The molecular mechanisms of PL and PC in AGA treatment were examined using experimental assays and network pharmacology. The AGA model was generated by topically applying 0.5% testosterone propionate in 70% ethanol solution to the backs of mice daily for 28 days while the normal-control (Normal-Con; no AGA induction) mice applied 70% ethanol. The 0.1% PL (AGA-PL), 0.1% PC (AGA-PC), 0.05% PL + 0.05% PC (AGA-MIX), and 0.1% cellulose (AGA-Con; control) were supplemented in a high-fat diet for 28 days in AGA-induced mice. Positive-control (AGA-Positive) were administered 2% finasteride daily on the backs of the AGA mice. Hair growth rates decreased in the order of AGA-PL, AGA-MIX, AGA-PC, AGA-Positive, and AGA-Con after 21 days of treatment (ED21). On ED28, skins were completely covered with hair in the AGA-PL and AGA-MIX groups. Serum testosterone concentrations were lower in the AGA-PL group than in the AGA-Con group and similar to concentrations in the Normal-Con group, whereas serum 17β-estradiol concentrations showed the opposite pattern with increasing aromatase mRNA expression (p < 0.05). In the dorsal skin, DKK1 and NR3C2 mRNA expressions were significantly lower, but TGF-β2, β-Catenin, and PPARG expressions were higher in the AGA-PL and AGA-PC groups than in the AGA-Con group (p < 0.05), whereas TNF-α and IL-6 mRNA expressions were lower in the AGA-PL, AGA-MIX, and Normal-Con groups than in the AGA-Con group (p < 0.05). The phosphorylation of Akt and GSK-3β in the dorsal skin was lower in AGA-Con than normal-Con, and PL and MIX ingestion suppressed their decrease similar to the Normal-Con. In conclusion, PL or PL + PC intake had beneficial effects on hair growth similar to Normal-Con. The promotion was related to lower serum testosterone concentrations and pro-inflammatory cytokine levels, and inhibition of the steroid hormone pathway, consistent with network pharmacology analysis findings.

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“…We hypothesised that Alzheimer's-like disease would exacerbate OA and IMF with a high-protein (H-P) diet would reverse or halt memory impairment and OA symptoms in oestrogendeficient animals with induced Alzheimer's-like disease and OA. We examined the hypothesis in OVX rats with the hippocampal infusion of amyloid-β (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and MIA injection into the articular cartilage of ad libitum or intermittently fasted rats with high fat (H-F) or H-P diets and explored the mechanisms involved.…”

mentioning

confidence: 99%

Intermittent fasting with a high-protein diet mitigated osteoarthritis symptoms by increasing lean body mass and reducing inflammation in osteoarthritic rats with Alzheimer’s disease-like dementia

Park

Shin²

2021

Br J Nutr

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Menopausal women are susceptible to osteoarthritis and memory impairment. We hypothesized that Alzheimer’s-like disease (AD) exacerbates osteoarthritis and that intermittent fasting(IMF) with a high-protein(H-P) diet would enhance memory function and relieve osteoarthritis symptoms in estrogen-deficient animals with surgically induced AD and osteoarthritis. The action mechanism was also explored. Ovariectomized Sprague-Dawley rats were fed high-fat(H-F) or H-P diets for two weeks, and then they had a hippocampal infusion of β-amyloid(25-35) for 4 weeks to induce AD and an injection of monoidoacetate(MIA) into the articular cartilage to induce osteoarthritis. Four groups had AD symptoms, whereas two groups had non-AD symptoms by hippocampal amyloid-β(35-25) infusion. All rats had an MIA injection into the articular cartilage of the left knee. IMF suppressed memory impairment in AD rats, especially those fed H-P diets. Compared to Non-AD, AD exacerbated osteoarthritis symptoms, including swelling, limping, slowed treadmill running speed, and uneven weight distribution in the left leg. The exacerbations were linked to increased inflammation and pain, but IMF and H-P lessened inflammation and pain-related symptoms. Lean body mass(LBM) also decreased with AD and IMF, but H-P protected against LBM loss. Histological examination of the knee joint revealed the degree of the cellular invasion into the middle zone, and the changes in the tidemark plateau were greatest in the AD-AL with H-F, while non-AD-IMF improved the cellular invasion to as much as non-AD-AL. H-P reduced the infiltration into the middle-zone of the knee and promoted collagen production. In conclusion, AD exacerbated the articular cartilage deterioration and memory impairment, and IMF with H-P alleviated the memory impairment and osteoarthritic symptoms by decreasing hippocampal amyloid-β deposition and proinflammatory cytokine expressions and by increasing LBM.

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Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

Cited by 22 publications

References 35 publications

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

Intermittent fasting with a high-protein diet mitigated osteoarthritis symptoms by increasing lean body mass and reducing inflammation in osteoarthritic rats with Alzheimer’s disease-like dementia

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