Tetrakis(acetonitrile)copper(I) Hexafluorophosphate–Promoted Efficient Synthesis of Amidoalkyl Naphthols Under Solvent-Free Conditions

Reaction between thiocarbamidoalkyl naphthols and acetylenic esters: An interesting cyclocondensation reaction for the synthesis of new thiazolidin-4-one derivatives

“…It is, therefore, not surprising that a considerable number of protocols for the synthesis of these compounds by three-component condensation of aldehydes, β-naphthol and acetonitrile or amides/carbamates or urea in the presence of different catalysts have been reported. [2][3][4][5] However, in consequence of the lower reactivity of the thio analogues of amide and urea, only limited published information regarding the replacement of amide with thioamide or thiourea are available in the literature. [6][7][8][9] The thioamido-and thiocarbamidoalkyl naphthols which were produced by these methods can be used as convenient building blocks in the synthesis of sulfur and nitrogen containing heterocyclic compounds.…”

Synthesis of 1-amidoalkyl-2-naphthols based on a three-component reaction catalyzed by boric acid as a solid heterogeneous catalyst under solvent-free conditions

“…The hypotensive and bradycardiac effects of these compounds have been evaluated [3][4]. The preparation of 1-amidoalkyl-2-naphthols can be carried out by multi-component condensation of aryl aldehydes, 2-naphthol and acetonitrile or amide in the presence of Lewis or Brønsted acid catalysts [5][6][7][8][9][10][11][12][13][14][15][16]. However, some of these catalysts suffer from the drawback of green chemistry such as prolonged reaction times, low yields and toxicity of the catalyst.…”