Tetralogy of Fallot Cardiac Function Evaluation and Intelligent Diagnosis Based on Dual-Source Computed Tomography Cardiac Images

Abstract

Tetralogy of Fallot (TOF) is the most common complex congenital heart disease (CHD) of the cyanotic type. Studies on ventricular functions have received an increasing amount of attention as the development of diagnosis and treatment technology for CHD continues to advance. Reasonable options for imaging examination and accurate assessment of preoperative and postoperative left ventricular functions of TOF patients are important in improving the cure rate of TOF radical operation, therapeutic evaluation, and judgment prognosis. Therefore, with the aid of dual-source computed tomography (DSCT), cardiac images with high temporal resolution and high definition, we measured the left ventricular time-volume curve using image data and calculating the left ventricular function parameters to conduct the preliminary evaluation on TOF patients. To comprehensively evaluate the cardiac function, the segmental ventricular wall function parameters were measured, and the measurement results were mapped to a bull's eye diagram to realize the standardization of segmental ventricular wall function evaluation. Finally, we introduced a new clustering method based on auto-regression model parameters and combined this method with Euclidean distance measurements to establish an intelligent diagnosis of TOF. The results of this experiment show that the TOF evaluation and the intelligent diagnostic methods proposed in this article are feasible.

Association of Oxidative Stress and Platelet Receptor Glycoprotein GPIbα and GPVI Shedding During Nonsurgical Bleeding in Heart Failure Patients With Continuous-Flow Left Ventricular Assist Device Support

“…Recently, it was shown that the non-physiological high shear stress (NPHSS) environment that occurs with CF-LVADs may be responsible for platelet dysfunction as evidenced by GPIbα, GPVI and GPIIbIIIa receptor shedding. 14–16 Understanding of the role of oxidative stress and NPHSS from CF-LVAD as contributory factor in platelet glycoprotein shedding may enable development of effective medical management strategy.…”

“…13 Studies also revealed that non-physiological high shear stress may also contribute to the shedding of different important platelet receptor glycoproteins. 14–16 Several biochemical pathways that induce shedding of GPIbα and/or GPVI have been identified. 17–21 While these pathways might be dependent or independent of platelet activation, the loss of these functional receptors may result in defective platelets.…”

Identification of clinically relevant phenotypes in patients with Ebstein anomaly

“…17 Cluster analysis has been used successfully to classify patients with congenital abnormalities into clinically relevant subgroups based on their phenotype, 18 including patient classification based on cardiac imaging. [19][20][21][22] Adequate sample size for cluster analysis was determined considering the number of variables, which may exponentially increase data dimensionality. For this purpose, an approach has been proposed in which meaningful classifications can be obtained using a sample size of 2 × , where x is the number of variables.…”

Improving medical image fusion method using fuzzy entropy and nonsubsampling contourlet transform

“…NSCT is proposed on the basis of CT and realized through nonsubsampled Laplace pyramid (LP) decomposition and nonsubsampled directional filter banks 29 . Figure 2 shows the structure of NSCT.…”