Tetralogy of Fallot in Spain: a nationwide registry-based mortality study across 36 years

Llamosas-Falcón, Laura; Bermejo‐Sánchez, Eva; Sánchez-Díaz, Germán; Villaverde-Hueso, Ana; Паз, Мануел Посада де ла; Alonso-Ferreira, Verónica

doi:10.1186/s13023-019-1056-y

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…In‐hospital mortality in our study (0.42%) was significantly lower than that in other similar studies 3 , 5 , 6 , 24 , 25 (ranging from 1.99% to 4.13%), but similar to the results from a previous study in Fuwai hospital 4 (0.24%). This might be mainly because some patients with a poor prognosis forewent treatment and died at home because of economic reasons and the national culture.…”

Section: Discussionsupporting

confidence: 89%

Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot

Luo

et al. 2021

JAHA

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Background Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Absolute lymphocyte count (ALC) is a low‐cost and easy‐to‐obtain inflammatory indicator; however, its association with the prognosis of patients with TOF remains unknown. This study aimed to determine the prognostic value of preoperative ALC in children with TOF. Methods and Results This retrospective study included 707 patients aged <6 years who underwent corrective operations for TOF between January 2016 and December 2018 in Fuwai Hospital, China. The end points were mortality, extracorporeal membrane oxygenation placement, postoperative hospital stay >30 days, and severe postoperative complications; patients were grouped on the basis of prognosis: poor prognosis (n=76) and good prognosis (n=631). Univariable and multivariable logistic regression analyses were performed to identify the independent risk factors for poor prognosis, on which a risk scoring system was based. The receiver operating characteristic curve was used to assess model performance. Using another model without ALC, the effect of the addition of ALC was assessed. Results suggested that ALC was an independent factor with a cutoff point of 4.36×10 9 /L. The addition of ALC improved the area under the curve from 0.771 to 0.781 ( P <0.001). To avoid reverse causality and further control for confounding factors, the patients were further divided on the basis of ALC level, and a propensity score matching was performed; 117 paired patients were identified for further analysis. Low ALC levels had an odds ratio of 3.500 (95% CI, 1.413–8.672). Conclusions Low preoperative ALC represents an independent predictor of poor prognosis in children with TOF.

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Section: Discussionsupporting

confidence: 89%

Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot

Luo

et al. 2021

JAHA

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“…Subsequently, they were discharged. In our study, the postoperative average stay was 11 ± 4 days, which was comparable to the study by Benbrik et al, who compared patients from developed and developing for shorter durations of mechanical ventilation, intensive care unit stays, and hospital stays [26].…”

Section: Postoperative Coursesupporting

confidence: 89%

Total Correction for Tetralogy of Fallot in Patients Weighing Over 10 kg: Experiences and Follow-Up Outcomes

Chandhar,

Pramanik,

Gupta

et al. 2024

Cureus

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Background Although the recommended time for total correction of tetralogy of Fallot (TOF) is during infancy, sometimes TOF cases present to healthcare setups after pre-school age, with some cases presenting even beyond adolescence in developing countries. The objective of this study was to assess patients with TOF weighing 10 kg and above who underwent definitive corrective surgical techniques such as transannular patch (TAP), valve-sparing right ventricular outflow tract (RVOT) pericardial patch augmentation, non-ventriculotomy infundibular resection for postoperative complications, hospital stay, and right ventricular (RV) dysfunction in the immediate postoperative period and subsequent outpatient department follow-ups. Methodology This comprehensive, retrospective cohort study included single-center data collected between January 16, 2018, and January 15, 2024. The study included 63 patients diagnosed with TOF weighing 10 kg and above, ensuring a robust and representative sample. Results Of the 119 patients who underwent total correction for TOF, 63 met the study’s inclusion criteria of TOF weighing above 10 kg. Of the 63 patients, 55.6% were males, and 44.4% were females. The mean weight of the study participants was 33.4 kg. The mean age was 15.9 years. Of the 63 patients, 39 underwent TAP surgery, 18 underwent RVOT patch augmentation, and six underwent total correction by non-ventriculotomy infundibular resection. There was a significant difference between the type of surgery groups and RV dysfunction, with the TAP group showing a higher incidence of RV dysfunction, indicating a potential risk factor associated with this technique. Conclusions Although TAP has significant immediate postoperative complications compared to other techniques, its long-term follow-up suggests that long-term survival and quality of life, as measured by major adverse cardiac events such as heart failure, arrhythmias, and reoperation rates, are commensurable in adulthood. This indicates that despite the initial challenges, TAP can provide satisfactory outcomes in the long run.

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“…Four deaths were reported from seventeen surgeries (23%) (19) that may be occurred due to the limited number of the patients and the status of techniques for surgeries at that time. During the recent decades the mortality rate of the TFTC surgery in the adult patients has decreased signi cantly (21). In the most of these studies the mortality rate ranged 1.8% to 8% (4,9,11,14,20,22).…”

Section: Discussionmentioning

confidence: 99%

Short-Term Outcomes Following Total Correction of Tetralogy of Fallot in Adult Patients

Khajali

Mohammadi

Maleki

et al. 2023

Preprint

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Objectivs: Tetralogy of Fallot (TOF) is a common congenital heart disease which should be corrected. The recommended time for the Tetralogy of Fallot Total Correction (TFTC) surgery is during the infancy for the possible difficulties during the surgery and the related issues. However, sometimes TOF is diagnosed and managed during the adulthood. Methods This study is a descriptive and retrospective one which included all patients who underwent TFTC at age of 15-year and older in a 10 -year period (between the years 2010 and 2020) to identify short-term (including in-hospital mortality, ICU Length of stay, respiratory complications after the surgery such as: pulmonary edema, pneumonia and etc. and bleeding after the surgery) and one-year (including left ventricle ejection fraction (LVEF), right ventricle (RV) ejection fraction, severity of tricuspid regurgitation and aortic regurgitation after surgery) outcomes. All data were taken from medical records at Shahid Rajaei Hear Center. Data were analyzed using SPSS 22. Results 94 patients with the mean age of 26.7 ± 9.6 years were enrolled. Most of them were male (59.6%) (P-value: 0.009). In-hospital mortality in our study were 5.3%. Tricuspid regurgitation (TR) was significantly resolved after the surgery (P-value: 0.006). Also, the correction of pulmonary size after the surgery was significant (P-value: 0.000). Conclusion This study showed that the surgery at older age is safe and the results are acceptable. Aging is not a contraindication for TFTC and surgery should be recommended if the patients are diagnosed with TOF at adulthood. Also, screening TOF in adult patients should be considered.

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Tetralogy of Fallot in Spain: a nationwide registry-based mortality study across 36 years

Cited by 8 publications

References 56 publications

Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot

Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot

Total Correction for Tetralogy of Fallot in Patients Weighing Over 10 kg: Experiences and Follow-Up Outcomes

Short-Term Outcomes Following Total Correction of Tetralogy of Fallot in Adult Patients

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