Tetralogy of Fallot: morphological variations and implications for surgical repair

Khan, Saad; Drury, Nigel E; Stickley, John; Barron, David J.; Brawn, William J.; Jones, Timothy J.; Anderson, Robert H.; Crucean, Adrian

doi:10.1093/ejcts/ezy474

Cited by 26 publications

(15 citation statements)

References 25 publications

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“…In 1963, the first transatrial transpulmonary repair by Hudspeth and colleagues was performed. This approach was revisited in the 1990s and is frequently used today in all age groups with a survival rate of greater than 99% and a low incidence of early intervention [10] .…”

Section: Discussionmentioning

confidence: 99%

Comparison between the Early Outcome of Fallot Repair with Preservation of the Pulmonary Valve Annulus versus Transannular Patch Repair

Attya¹,

Bastawisy

2019

The Medical Journal of Cairo University

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Background: This disease of heart is named after Fallot who correlated the pathologic and clinical manifestations of this cardiac malformation in his description of L'anatomie pathologique de la maladie bleu by 1888. He was the first to appreciate the complex of this cardiac malformation which he coined a "Tetralogy" consisting of pulmonary stenosis, Ventricular Septal Defect (VSD), dextroposition of the aorta, and RV hypertrophy. Aim of Study:To collect, review and analyze the data of Fallot patient undergoing total repair and to compare the early outcome of Fallot repair with preservation of the annulus versus transannular patch.

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Section: Discussionmentioning

confidence: 99%

Comparison between the Early Outcome of Fallot Repair with Preservation of the Pulmonary Valve Annulus versus Transannular Patch Repair

Attya¹,

Bastawisy

2019

The Medical Journal of Cairo University

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“…Tetralogy of Fallot (TOF) is a type of congenital cardiac disease affecting around 3%oo individuals ( Apitz et al, 2009 ; Khan et al, 2019 ). Four typical defects of TOF comprise pulmonary stenosis, ventricular septal defect, right ventricular (RV) hypertrophy, and overriding aorta.…”

Section: Introductionmentioning

confidence: 99%

The Optimal Tetralogy of Fallot Repair Using Generative Adversarial Networks

Zhang

Mao

et al. 2021

Front. Physiol.

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BackgroundTetralogy of Fallot (TOF) is a type of congenital cardiac disease with pulmonary artery (PA) stenosis being the most common defect. Repair surgery needs an appropriate patch to enlarge the narrowed artery from the right ventricular (RV) to the PA.MethodsIn this work, we proposed a generative adversarial networks (GANs) based method to optimize the patch size, shape, and location. Firstly, we built the 3D PA of patients by segmentation from cardiac computed tomography angiography. After that, normal and stenotic areas of each PA were detected and labeled into two sub-images groups. Then a GAN was trained based on these sub-images. Finally, an optimal prediction model was utilized to repair the PA with patch augmentation in the new patient.ResultsThe fivefold cross-validation (CV) was performed for optimal patch prediction based on GANs in the repair of TOF and the CV accuracy was 93.33%, followed by the clinical outcome. This showed that the GAN model has a significant advantage in finding the best balance point of patch optimization.ConclusionThis approach has the potential to reduce the intraoperative misjudgment rate, thereby providing a detailed surgical plan in patients with TOF.

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“…6 There are a number of variants of Tetralogy of Fallot, with variations in types of VSDs, coronary arterial patterns, and differences in aortic override. 7 However, this literature review will not go into these variations in detail.…”

Section: Introductionmentioning

confidence: 99%

Tetralogy of Fallot—A literature review

Muirhead

2020

Sonography

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Tetralogy of Fallot is a combination of four specific cardiac abnormalities. (a) A ventricular septal defect (VSD), (b) pulmonary valve stenosis/right ventricular outflow tract obstruction, (c) aorta overriding the VSD, and (d) right ventricular hypertrophy. This review attempts to outline the current literature regarding embryology, morphology, pathophysiology, ultrasound appearances and the current treatments/outcomes of infants with Tetralogy of Fallot. Tetralogy of Fallot is the most commonly occurring conotruncal anomaly. Here, the aim is to present the ultrasound features, with examples of Tetralogy of Fallot along with the story post birth in terms of surgical treatment. This information was gathered doing a literature search using PubMed and the University of South Australia library database, as well as through information provided by the Royal Children's Hospital Cardiology department, via fact sheets. With early diagnosis under ultrasound, preparations can be made and counseling provided to organize for intervention and further assessment after birth. With current surgical intervention, the survival rate past the age of 10 is now over 92%, when, 50 years ago, it was only 50%.

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Tetralogy of Fallot: morphological variations and implications for surgical repair

Cited by 26 publications

References 25 publications

Comparison between the Early Outcome of Fallot Repair with Preservation of the Pulmonary Valve Annulus versus Transannular Patch Repair

Comparison between the Early Outcome of Fallot Repair with Preservation of the Pulmonary Valve Annulus versus Transannular Patch Repair

The Optimal Tetralogy of Fallot Repair Using Generative Adversarial Networks

Tetralogy of Fallot—A literature review

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