Tetramethyl-O-scutellarin isolated from peels of immature Shiranuhi fruit exhibits anti-inflammatory effects on LPSinduced RAW264.7 cells

Hyun, Ju Mi; Jo, Yeon Jeong; Kim, Jung Eun; An, Hyun Joo; Choi, Young Hun; Hyun, Chang‐Gu; Lee, Nam Ho

doi:10.4314/tjpr.v16i9.22

Cited by 11 publications

(9 citation statements)

References 18 publications

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“…Among PMFs, [tetraMF+H] + ( m / z 343.12) was detected as the strongest peak in agreement with the previous work . PMFs have attracted attention as bioactive compounds in citrus peels owing to their anti-inflammatory, anticarcinogenic, antiatherogenic, and hepatoprotective effects. , …”

Section: Resultssupporting

confidence: 89%

“…13 PMFs have attracted attention as bioactive compounds in citrus peels owing to their anti-inflammatory, anticarcinogenic, antiatherogenic, and hepatoprotective effects. 26,27 Figure 6c shows the mass spectrum of the juice of an immature orange. [(Proline betaine)+K] + , [(citric acid)+K] + , and [(citric acid) 2 +K] + were detected as major ions.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Component Profiling in Agricultural Applications Using an Adjustable Acupuncture Needle for Sheath-Flow Probe Electrospray Ionization/Mass Spectrometry

Hiraoka

Rankin‐Turner

Ninomiya

et al. 2019

J. Agric. Food Chem.

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In previous work, probe electrospray ionization/mass spectrometry (PESI/MS) and sheath-flow probe electrospray ionization/mass spectrometry (sfPESI/MS) were reported for the rapid and minimally invasive analysis of food. In this work, a modified version of sfPESI will be reported. The sample surface was pricked with an acupuncture needle inserted in the sfPESI probe that protruded from the terminus of the tip by 5 mm. The invasion depth of the needle into the sample was ∼1 mm. After sampling, the needle was retracted into the solvent-preloaded capillary with a protrusion length of 0.1−0.2 mm from the tip. A mass spectrum of the sample captured on the needle was obtained by applying a high voltage to the needle. This method could be applicable to profiling analyses of plants with the epicuticular wax covering on the surfaces that are difficult to analyze by sf-PESI. The on-site mass spectrometric analysis for a growing apricot in the field was performed to monitor the developing stage of the fruit.

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Section: Resultssupporting

confidence: 89%

Section: ■ Results and Discussionmentioning

confidence: 99%

Component Profiling in Agricultural Applications Using an Adjustable Acupuncture Needle for Sheath-Flow Probe Electrospray Ionization/Mass Spectrometry

Hiraoka

Rankin‐Turner

Ninomiya

et al. 2019

J. Agric. Food Chem.

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“…Furthermore, evidence shows that tetramethyl-O-scutellarin reveals moderate reducing effect on NO generation within macrophages (IC 50 = 57.4 µM). In addition, the mediator PGE 2 together with several relevant cytokines, namely, IL-1β, IL-6 and TNF-α, were also inhibited to varying degrees after treatment, indicating tetramethyl-O-scutellarin indeed possessed certain anti-inflammatory activities (Hyun et al, 2017).…”

Section: Lps-induced Inflammationmentioning

confidence: 96%

“…Instead of being isolated from citrus peels, pentamethylquercetin can be easily synthesized from quercetin (Chen et al, 2011). Moreover, tetramethyl-Oscutellarin is also a newly identified citrus PMF which specifically exists in the pericarp of immature Shiranuhi fruit, revealing that the ripeness of citrus fruit may largely change the PMF constituent inside the peel part (Hyun et al, 2017).…”

Section: Chemistry Of Citrus Peel Pmfsmentioning

confidence: 99%

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Wang¹,

Li²,

Wei³

et al. 2018

Journal of Food Bioactives

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Inflammation is a non-specific kind of biological immune response of body tissues to any type of external or internal injuries, such as pathogens, irritants and immune stress reactions. There are two types of inflammation, namely acute and chronic. Acute inflammation starts and develops rapidly, and is aroused by various factors, including injuries, infection, toxins or immune reactions. Chronic inflammation usually lasts for an extended long period of time and results from elimination failure of acute inflammation, autoimmune disorders, various pathogens and pathogenic environments. Except for the damage itself, there exists a direct and intimate connection between chronic inflammation and various clinic common diseases, such as neurodegeneration, as well as metabolic and cardiovascular ailments. Citrus peel is a by-product generated in citrus juice processing. Polymethoxyflavones (PMFs) exist abundantly and almost exclusively in citrus peels, and their biological activities have been broadly investigated in recent years. PMFs have proven to possess potential inhibitory bioactivities towards a number of functional and immune diseases including inflammation. The two most abundant PMFs exhibiting prominent bioactivities in citrus peels are nobiletin and tangeretin, ubiquitously detected in various citrus species. In this review, the beneficial health effects and the underlying molecular mechanisms of ten main citrus PMFs were illustrated against numerous inflammatory diseases, including inflammatory bowel disease (IBD), neuroinflammation and organ inflammation, among others.

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“…In addition, the peel of a tangerine is used in drinks and baking in Western countries as an aromatic spice [25][26][27]. Citrus fruit peels are reported to be used in Chinese medicine to treat muscle pain, stomachache, cough, skin inflammation and high blood pressure [28]. Wampee (Clausena lansium) peels are used to treat bronchitis and stomachache in China and Indian folk medicine [29].…”

Section: Traditional Uses Of Fruit Peelsmentioning

confidence: 99%

Fruit Peels: Food Waste as a Valuable Source of Bioactive Natural Products for Drug Discovery

Hussain

Mamadalieva

Hussain

et al. 2022

CIMB

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Fruits along with vegetables are crucial for a balanced diet. These not only have delicious flavors but are also reported to decrease the risk of contracting various chronic diseases. Fruit by-products are produced in huge quantity during industrial processing and constitute a serious issue because they may pose a harmful risk to the environment. The proposal of employing fruit by-products, particularly fruit peels, has gradually attained popularity because scientists found that in many instances peels displayed better biological and pharmacological applications than other sections of the fruit. The aim of this review is to highlight the importance of fruit peel extracts and natural products obtained in food industries along with their other potential biological applications.

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Tetramethyl-O-scutellarin isolated from peels of immature Shiranuhi fruit exhibits anti-inflammatory effects on LPSinduced RAW264.7 cells

Cited by 11 publications

References 18 publications

Component Profiling in Agricultural Applications Using an Adjustable Acupuncture Needle for Sheath-Flow Probe Electrospray Ionization/Mass Spectrometry

Component Profiling in Agricultural Applications Using an Adjustable Acupuncture Needle for Sheath-Flow Probe Electrospray Ionization/Mass Spectrometry

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Fruit Peels: Food Waste as a Valuable Source of Bioactive Natural Products for Drug Discovery

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