Tetramethylguanidinium Azide (TMGA) - A Versatile Azidation Agent

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research Tetramethylguanidinium Azide (TMGA) -A Versatile Azidation AgentCompiled by Roman Błaszczyk Roman Błaszczyk was born in Sieradz, Poland in 1980. He received his M.Sc. ( 2004) in Organic Chemistry from the Technical University of Lodz, Poland. He is currently working towards his PhD under the supervision of Prof. Tadeusz Gajda at the same university. His research interests include asymmetric synthesis of new aminophosphonic acids, azido-and vinylphosphonates.

Guanidines in Organic Synthesis

“…TMGA (28) is commercially available, nontoxic and safe to handle [107]. Thus, TMGA (28) participating azidation has been established as a widely applicable and simple operating method for the introduction of a nitrogen source in a variety of organic syntheses [108].…”