Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes

Zhou, Tianjun; Wang, Sheng; He, Jie; Bian, Yangyang

doi:10.3892/mmr.2021.12528

Cited by 10 publications

(5 citation statements)

References 46 publications

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“… 71 Tricetin repressed the expression of MMPs and IL‐1β‐induced NO and PGE2 production, while markedly attenuating IL‐1β‐induced phosphorylation of JNK and p38, exerting antiapoptotic effects via Bax/Bcl‐2/caspase‐3. 94 Tetramethylpyrazine protects chondrocytes by reducing endoplasmic reticulum stress through inhibition of IL‐1β‐induced GRP78 and CHOP expression, 95 which is likely to be a potential therapeutic agent for osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects

Wang

Qian

Xiao

et al. 2023

Immunity Inflam & Disease

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Background: Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease. Methods: This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results: IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-KB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis. Conclusion: This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.

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Section: Introductionmentioning

confidence: 99%

Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects

Wang

Qian

Xiao

et al. 2023

Immunity Inflam & Disease

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“…113,114 There are numerous studies to confirm the function of phytochemicals in inhibiting chondrocyte apoptosis, as well as in anti-inflammation and regulating ECM metabolism (Table 2). [115][116][117][118][119][120][121][122][123] In addition, it has long been confirmed that TCM prescriptions or Chinese patent medicines also have excellent ability to treat OA. Serum containing Danzikang Knee Joint Granules promoted the proliferation of stem cells and cartilage differentiation in OA rats and reduced the apoptosis rate of chondrocytes.…”

Section: Phytochemicalsmentioning

confidence: 99%

“…There are numerous studies to confirm the function of phytochemicals in inhibiting chondrocyte apoptosis, as well as in anti‐inflammation and regulating ECM metabolism (Table 2). 115–123 …”

Section: Apoptosismentioning

confidence: 99%

“…As mentioned above, there is a close relationship between pyroptosis and inflammation, that is to say, when we formulate treatment strategies for OA, inflammation and pyroptosis must be considered together 115 . NF‐κB is a typical inflammatory signaling pathway that mediates the inflammatory response in a variety of diseases.…”

Section: Pyroptosismentioning

confidence: 99%

“…169,170 Treatment Strategies for Pyroptosis in OA As mentioned above, there is a close relationship between pyroptosis and inflammation, that is to say, when we formulate treatment strategies for OA, inflammation and pyroptosis must be considered together. 115 NF-κB is a typical inflammatory signaling pathway that mediates the inflammatory response in a variety of diseases. Both loganin and morroniside have been confirmed to reduce chondrocyte pyroptosis and inflammation response through inhibiting activation of NF-κB.…”

Section: Pyroptosis In Oamentioning

confidence: 99%

See 2 more Smart Citations

Recent Therapeutic Strategies for Excessive Chondrocyte Death in Osteoarthritis: A Review

Xiang

Zheng

Liu

et al. 2023

Orthopaedic Surgery

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Osteoarthritis (OA) causes pain and disability in the elderly and has placed a severe burden on healthcare worldwide. Excessive death and decreased density of chondrocytes are recognized as the major pathological characteristic of OA. Chondrocytes have been shown to have multiple forms of death, including apoptosis, pyroptosis, necroptosis, and ferroptosis. The excessive death of chondrocytes often forms a vicious circle with imbalanced chondrocytes extracellular matrix (ECM) metabolism. Therefore, inhibiting chondrocytes excessive death has become a key point that cannot be ignored in the development of OA treatment strategies. We summarized recent studies on the functions and mechanisms of different modes of chondrocyte death and potential therapeutic strategies for OA and offered our views. This may provide direction and theoretical support for formulating OA treatment strategies in the future.

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Tetramethylpyrazine: A review on its mechanisms and functions

Lin

Wang

Zhou

et al. 2022

Biomedicine & Pharmacotherapy

103

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Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes

Cited by 10 publications

References 46 publications

Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects

Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects

Recent Therapeutic Strategies for Excessive Chondrocyte Death in Osteoarthritis: A Review

Tetramethylpyrazine: A review on its mechanisms and functions

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