Tetranucleotide repeat polymorphism at the human thyroid peroxidase (hTPO) locus

Anker, R; Steinbrueck, Todd; Donis-Keller, Helen

doi:10.1093/hmg/1.2.137

Cited by 111 publications

(46 citation statements)

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“…We genotyped unrelated individuals of African descent, 68 from the Bananal community and 76 from Jequié, for the following human short tandem repeat (STR) microsatellite autosomic polymorphic loci and their alleles: the CSF1PO CSF-1 receptor gene c-fms proto-oncogene (Edwards et al 199;Hammond et al (1994); the TPOX thyroid peroxidase gene (Anker et al, 1992); the TH01 tyrosine hydroxylase gene (Polymeropoulos et al, 1991a); the vWA von Willebrand factor gene (Kimpton et al, 1992); the F13A1 coagulation factor XII subunit gene (Polymeropoulos et al, 1991b); and the FES/FPS c-fes/fps protooncogene (Polymeropoulos et al, 1991c).…”

Section: Laboratory Analysesmentioning

confidence: 99%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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The African descent population of the Bananal community in the Brazilian state of Bahia (BA) was characterized as a genetic isolate and analyzed for some short tandem repeat (STR) microsatellite autosomic polymorphic loci (CSF1PO, TH01, TPOX, F13A1, FESFPS and vWA). These genetic variants were further compared to data obtained from an urban sample from the town of Jequié (BA) regarding demographic and anthropogenetic aspects. The Bananal sample comprised 32 unrelated individuals whereas Jequié was represented by 76 individuals. The Bananal Negroid Phenotypic Index (NPI) was 0.98 and the Negroid Cultural Index (NCI) 0.24. Consanguineous marriages occurred at a frequency of 34.61% and the F value was 0.0126. All six loci studied were in Hardy-Weinberg Equilibrium (p > 0.05). The genotypic and allele frequencies of the CSF1PO and vWA loci were similar. In the Bananal population the genic diversity of the THO1 locus was 66.8% and that of the F13A1 locus was 83.7%. The estimated ethnic racial admixture was 81% African and 19% Amerindian. The multiple correlation coefficient (R 2 ) indicated adequate adaptation (99%). Total genetic variation for the six loci was 82.9% with an index of 6.7% for population subdivision (G ST ' = 0.067). Anthropologic data and results obtained from the allele frequencies of the loci studied are indicative of a genetic isolate in Bananal, reminiscent of the a`quilombo community' (i.e. one founded by run away slaves).

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Section: Laboratory Analysesmentioning

confidence: 99%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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“…However these primers were not designed for use in multiplex PCR. Here we report on a``Small TCT Multiplex'' that simultaneously ampliˆes the three STR loci; TH01 1) , CSF1PO 9) and TPOX 10) with reduced length amplicons, and demonstrate the utility of this multiplex system for typing from degraded DNA.…”

Section: Introductionmentioning

confidence: 90%

A New Procedure for the Multiplex PCR Amplification of TH01, CSF1PO and TPOX Loci with Small Amplicon Lengths.

Fujii

Senju

Yoshida

et al. 2002

Jpn. J. Sci. Tech. Iden.

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We describe a new procedure for the multiplex PCR ampliˆcation of the three short tandem repeat (STR) loci; TH01, CSF1PO and TPOX with small amplicon lengths (the Small TCT Multiplex). The accuracy of the Small TCT Multiplex was veriˆed by typing 100 Japanese samples that had been previously typed using an AmpFlSTR Green I PCR ampliˆcation kit (Green I Kit). The results using the Small TCT Multiplex were consistent with those obtained by the Green I Kit. STR typing using the Small TCT Multiplex was examined from 36 bloodstain samples that had been left for 1 to 25 years at room temperature and compared to that using the Green I Kit. The Small TCT Multiplex was superior to the Green I Kit for STR typing especially in the case of bloodstain samples that had aged for more than 8 years.

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“…reaction buffer (Perkin Elmer), 0. The primers used in this study (hTPO [4], THO1 [5], FGA [6]) correspond to the underlined bases given in the sequence data in Results and Discussion.…”

Section: Methodsmentioning

confidence: 99%

The Short Tandem Repeat Loci hTPO, THO1 and FGA

et al. 1998

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This paper focuses on the three well-established short tandem repeats HumhTPO (human thyroid peroxidase gene), HumTHO1 (human tyrosine hydroxylase gene) and HumFGA (human alpha fibrinogen gene). We present sequencing data which include the sequences of all the different primer pairs used so far, as well as results from a population study which was carried out on an American Black and a southwestern German population. All data are compared with previously published studies. A test for homogeneity confirmed that non-European populations possess different genetic pools for each of the three loci under investigation.

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Tetranucleotide repeat polymorphism at the human thyroid peroxidase (hTPO) locus

Cited by 111 publications

References 0 publications

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

A New Procedure for the Multiplex PCR Amplification of TH01, CSF1PO and TPOX Loci with Small Amplicon Lengths.

The Short Tandem Repeat Loci hTPO, THO1 and FGA

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