Tetraphenylpyrazine-Based Luminescent Metal–Organic Framework for Chemical Sensing of Carcinoids Biomarkers

Abstract

A new non-interpenetrated three-dimensional (3D) pillared-layered TPP-based LMOF [Zn3(TPyTPP)0.5(BDC)3]·8DMF (denoted as Zn-MOF 1) was successfully prepared (TPyTPP = tetrakis­(4-(pyridin-4-yl)­phenyl)­pyrazine and H2BDC = 1,4-benzenedicarboxylic acid). Zn-MOF 1 was characterized by single-crystal X-ray diffraction, PXRD, IR, N2 adsorption, thermogravimetric analysis, and luminescent spectrum. Impressively, luminescent sensing studies reveal that activated Zn-MOF 1 not only displays excellent luminescence-quenching efficiency with the values of high K sv and low LODs toward 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, but also possesses outstanding sensing characteristics in terms of fast response, high sensitivity, and specific selectivity. Zn-MOF 1 performs as efficient sensing of carcinoid biomarkers to provide a fresh detection platform for the diagnosis of carcinoids. In addition, the sensing mechanism was also explored on the basis of ultraviolet–visible (UV–vis) absorption, DFT calculations, and structural analysis.

Zinc (II) and AIEgens: The “Clip Approach” for a Novel Fluorophore Family. A Review

“…A MOF of the series was used as a fluorescent probe for detecting copper (II) ions in a wide concentration range (1–100 nM) with LOD = 550 pM and for on-site determination of glucose in real serum samples. Recently, Liang Shen and coworkers [ 154 ] produced a non-interpenetrated three-dimensional tetraphenylpyrazine (TPP)-based LMOF (denoted as Zn-MOF1) starting from TPyTPP = tetrakis(4-(pyridin-4-yl)phenyl)pyrazine and H2BDC = 1,4-benzenedicarboxylic acid. Zn-MOF1 displays excellent luminescence-quenching sensitivity toward 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) with LODs of 0.50 μM for 5-HT and 0.57 μM for 5-HIAA.…”

Luminescent Zn (II)-Based Nanoprobes: A Highly Symmetric Supramolecular Platform for Sensing of Biological Targets and Living Cell Imaging

“…Yu Tang and coworkers in 2017 (Cai et al, 2017) produced a core-shell MOF-based nanocomposite UCNPs/MB@ The employ of fluorescence AIE (aggregation induced enhancement) active markers state exhibit stronger emission in the concentred solution (Caruso et al, 2018;Diana and Panunzi, 2021) than in diluted ones. AIE undergoing probes can solve problems due to fluorescence quenching of the aggregates in aqueous physiologic media and are very useful in bioimaging (Fan et al, 2020b;Ying et al, 2021). Dongdong Sun and coworkers in 2019 (Zhang et al, 2019) fabricated gold nanoprisms (AuNPR) conjugated to phenanthroline derivatives functionalized tetraphenylethene (TPE) with aggregation induced enhancement (AIE) of fluorescence.…”

Exclusive Feature Papers in Colorants

“…A MOF of the series was used as a fluorescent probe for detecting copper (II) ions in a wide concentration range (1-100 nM) with LOD = 550 pM and for on-site determination of glucose in real serum samples. Recently, Liang Shen and coworkers [154] produced a non-interpenetrated three-dimensional tetraphenylpyrazine (TPP)-based LMOF (denoted as Zn-MOF1) starting from TPyTPP = tetrakis(4-(pyridin-4-yl)phenyl)pyrazine and H2BDC = 1,4-benzenedicarboxylic acid. Zn-MOF1 displays excellent luminescence-quenching sensitivity toward 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) with LODs of 0.50 µM for 5-HT and 0.57 µM for 5-HIAA.…”