Tetraspanins and vascular functions

Abstract

Tetraspanins are multiple membrane-spanning proteins that likely function as the organizers of membrane microdomains. Tetraspanins associate with other membrane-bound molecules such as cell-adhesion proteins, growth factor receptors, and Ig superfamily members and regulate key cellular processes such as adhesion, migration, and fusion. Tetraspanins are widely expressed in vascular and haematopoietic cells and are involved in both physiological and pathological processes related to angiogenesis, vascular injury, thrombosis, and haemostasis. A wide body of evidence suggests that tetraspanins directly regulate the development and functions of the vascular system and the pathogenesis of vascular diseases. This article reviews current understanding of the roles of tetraspanins in vascular functions.

Influence of Soluble Placental Tissue-Derived Molecules Upon Expression of Adhesion Molecules by EA.HY926 Endothelial Cells

“…Снижение экспрес-сии CD9 может приводить к нарушению ангио-генеза, поскольку данная молекула принимает участие в миграции ЭК и их межклеточном взаи-модействии [35]. Экспрессия остальных исследо-ванных адгезионных молекул эндотелиальными клетками под влиянием факторов, секретируе-мых тканью плаценты при гестозе, не изменялась по сравнению с третьим триместром физиологи-ческой беременности.…”

Ancient cardiac myxomas – another point of view in the light of tetraspanins

“…They belong to the transmembrane 4 superfamily of transmembrane proteins, and most of them build cholesterol-rich tetraspanin-enriched microdomains (TEMs) [29,30]. Tetraspanins usually are expressed on platelets and on components of the vascular system, where they have a clear role in endothelial proliferation, neo-vascularization, smooth muscle fiber motility and contraction, cell motility, adhesion and, importantly, maintenance of the extracellular micro-environment.…”

“…Tetraspanins usually are expressed on platelets and on components of the vascular system, where they have a clear role in endothelial proliferation, neo-vascularization, smooth muscle fiber motility and contraction, cell motility, adhesion and, importantly, maintenance of the extracellular micro-environment. CD9 (p24), as the main protein member of this family, interacts with many integrins, growth factors including heparin-binding epidermal growth factor (HB-EGF), epidermal growth factor receptor (EGFR) with metalloproteinases, and immunoglobulins [29]. CD63 exhibits an entirely different structure.…”

“…It is involved in transmembrane transport of various agents, cell motility and interactions with extracellular mediators by the trafficking phenomenon [29].…”

CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension

“…Indeed, by differentially associating with integrins and other membrane molecules, tetraspanins such as CD9, CD151, CD63 and TSSC6 take part in diverse vascular events including smooth muscle cell (SMC) proliferation and migration, endothelial cell adhesion, platelet aggregation and thrombosis, angiogenesis, and haemostasis. 50 The biology of vascular tetraspanins and their regulatory roles in the pathophysiological processes related to cardiovascular system become better understood recently. 50 However, the expression and function of most newly identified tetraspanins in the vascular system remain to be elucidated.…”