Tetraspanins as Regulators of Protein Trafficking

Odintsova, Elena; Berditchevski, Fedor

doi:10.1007/978-94-007-6070-7_5

Cited by 1 publication

(1 citation statement)

References 112 publications

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“…In addition, several tetraspanins, in particular CD9, CD82 and CD151, associate with and/or modulate downstream signalling of tyrosine kinase receptors, including epithelial growth factor receptor (EGFR), ERBB2, c-MET and vascular endothelial growth factor receptor (VEGFR)-3 (also known as FLT4) (Franco et al, 2010;Iwasaki et al, 2013;Murayama et al, 2008;Novitskaya et al, 2014;Odintsova et al, 2003;Sridhar and Miranti, 2006;Takahashi et al, 2007). However, so far, there is no evidence that a particular tetraspanin associates directly with these receptors.…”

Section: Regulation Of Membrane-anchored Enzymes and Growth Factor Simentioning

confidence: 99%

Tetraspanins at a glance

Charrin

Jouannet

Boucheix

et al. 2014

Journal of Cell Science

377

371

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Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer progression. Many tetraspanins associate specifically and directly with a limited number of proteins, and also with other tetraspanins, thereby generating a hierarchical network of interactions. Through these interactions, tetraspanins are believed to have a role in cell and membrane compartmentalization. In this Cell Science at a Glance article and the accompanying poster, we describe the basic principles underlying tetraspaninbased assemblies and highlight examples of how tetraspanins regulate the trafficking and function of their partner proteins that are required for the normal development and function of several organs, including, in humans, the eye, the kidney and the immune system.

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