Tetrazepam: an allergen with several clinical expressions

Occupational airborne contact dermatitis from benzodiazepines and other drugs

“…2), except for tetrazepam, a muscle relaxant. Recently, occupational allergic contact dermatitis caused by this molecule in nurses having to crush tablets for geriatric people or patients with difficulties in swallowing has been increasingly reported (1,(3)(4)(5)(6)(7). Cases have also been described in the pharmaceutical industry, owing to exposure during the production process or machine maintenance (8,9).…”

Photodermatitis from tetrazepam

“…Benzodiazepines cause rare Type IV hypersensitivity reactions (1) that are generally positive on patch testing (2)(3). Fixed drug eruption, generalized reactions, contact dermatitis, leucocytoclastic vasculitis, erythema multiforme, photo-onycholysis and photosensitivity (4)(5)(6)(7)(8) have also been reported. Cross-reaction between diazepam and tetrazepam has been demonstrated (9).…”

Occupational allergic contact dermatitis from tetrazepam in nurses

“…or Myolastan ® crushed tablet as is, 1% aq. and ≥ 10% pet., were negative in 155 control patients (3, 6–8, 11–16).…”

“…Both allergic contact dermatitis and drug eruptions following ingestion of tetrazepam have been described in the literature. In our search (PubMed) we found seven cases of occupational allergic contact dermatitis from tetrazepam: one occurred in a mother crushing Myolastan ® tablets for her daughter (1), three in nurses (2–4), and three in pharmaceutical manufacturing workers (5, 6). All patients suffered from airborne contact dermatitis with lesions on the face and neck, and three of them also had erythema or eczema on the fingers and dorsum of the hands.…”