Tetrazolopyrimidine-tethered phenothiazine molecular hybrids: synthesis, biological and molecular docking studies

Abstract

Molecular hybrids integrating phenothiazine and tetrazolopyrimidine structural motifs (5a-5c, 6a-6c, 7a-7b, 8a and 9a-9b) were designed and synthesized from phenothiazine by adopting a multi-step synthetic strategy involving alkylation, Vilsmeier-Haack, and...