Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Kandouz, Mustapha; Alachkar, Amal; Zhang, Li; Dekhil, Hafedh; Chehna, Fawaz; Yasmeen, Amber; Moustafa, Ala-Eddin Al

doi:10.1016/j.jep.2009.10.035

Cited by 49 publications

(44 citation statements)

References 31 publications

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“…Although it has been reported that PC-3 cells are negative for E-Cadherin (Nakamura et al, 2003), the results of our immunofluorescence microscopy and western blotting experiments showed that in fact, these cells express E-Cadherin, however, the protein does not appear to be localized at the cell membranes and it has a diffuse staining pattern inside the cells ( Figure 5B and not shown). A similar observation has been reported by another research group (Kandouz et al, 2010). Therefore, we tested whether the extract of T persicum had any effect on E-Cadherin cellular localization.…”

Section: Sublethal Concentrations Of T Persicum Extract Induce An Episupporting

confidence: 91%

“…T persicum extract induced an epithelial-like phenotype in PC-3 cells together with cell membrane localization of E-Cadherin and β-Catenin proteins ( Figure 5 and Figure 6). PC-3 prostate cancer cells have a mesenchymal phenotype and are very invasive and produce tumors in laboratory animals (Zhou et al, 2009;Kandouz et al, 2010;Zhang and Waxman, 2010;Tai et al, 2011). Our results showed that in these cells, both E-Cadherin and β-Catenin proteins were cytoplasmic and cells having either protein at the cell membrane were extremely rare (Figures 5 and 6).…”

Section: Discussionmentioning

confidence: 66%

“…In this work, we studied the anticancer properties of Teucrium persicum, an endemic plant of Iran (Monsef-Esfahani et al, 2010). For the study, we chose PC-3 prostate cancer cells which are very invasive, poorly differentiated and have a mesenchymal phenotype (Kandouz et al, 2010;Tai et al 2011). Therefore, this cell line is an excellent choice to study several anti-cancer features of a candidate compound.…”

Section: Discussionmentioning

confidence: 99%

“…The species are mainly distributed in central and southern America, southeast Asia, and Mediterranean region (Kandouz et al, 2010;Miri et al, 2012). The extract isolated from Teucrium species has been used for treatment of diabetes, obesity, inflammation, and hyperlipidemia (Twaij et al, 1987;Tariq et al, 1989;Miri et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Here, PC-3 prostate cancer cells have been used to study the biological properties of T persicum. PC-3 cells are highly invasive and have a mesenchymal phenotype (Kandouz et al, 2010;Tai et al, 2011). Therefore, this cell line is an appropriate tool to study anti-cancer properties of plant extracts and theirderived compounds (Nyska et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Tafrihi

Toosi²,

Minaei³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and β-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity

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Section: Sublethal Concentrations Of T Persicum Extract Induce An Episupporting

confidence: 91%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Tafrihi

Toosi²,

Minaei³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

Bahramikia

Yazdanparast

2012

Phytotherapy Research

120

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Teucrium polium L. (family Lamiaceae) is a wild-growing flowering plant, found abundantly in South-Western Asia, Europe and North Africa. Traditionally, T. polium has been used for different pathological conditions such as gastrointestinal disorders, inflammations, diabetes and rheumatism. In traditional Iranian medicine (TIM), the tea of T. polium is used for treating many diseases such as abdominal pain, indigestion, common cold and type 2 diabetes. Based on this background, many studies have been followed for scientific confirmation of the above-mentioned properties. In this review, 100 articles published from 1970 to 2011 in the area of phytochemistry, pharmacology and toxicology of extracts and compounds isolated from T. polium have been evaluated. During the past 40 years, different classes of compounds have been isolated from various parts of T. polium of which the main groups are terpenoids and flavonoids. It has been found that these compounds possess a broad spectrum of pharmacological effects including antioxidant, anticancer, antiinflammatory, hypoglycemic, hepatoprotective, hypolipidemic, antibacterial and antifungal. The results of data analyses on the chemical, pharmacological and toxicological characteristics of T. polium support the view that this plant has beneficial therapeutic properties. However, further studies to identify the active components and further verify their relevant pharmacological activities are warranted.

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Anticancer Activity of Secondary Metabolites of Teucrium Species

Milutinović

Cvetković

2020

Teucrium Species: Biology and Applications

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Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Cited by 49 publications

References 31 publications

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

Anticancer Activity of Secondary Metabolites of Teucrium Species

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