Based on tree-level open-string scattering amplitudes in the low string-scale scenario, we derive the massless fermion scattering amplitudes. The amplitudes are required to reproduce those of the Standard Model at tree level in the low energy limit. We then obtain four-fermion contact interactions by expanding in inverse powers of the string scale and explore the constraints on the string scale from low energy data. The Chan-Paton factors and the string scale are treated as free parameters. We find that data from the neutral and charged current processes at HERA, Drell-Yan process at the Tevatron, and from LEP-II put lower bounds on the string scale M S , for typical values of the Chan-Paton factors, in the range M S ≥ 0.9 − 1.3 TeV, comparable to Tevatron bounds on Z ′ and W ′ masses.