2021
DOI: 10.1186/s12859-021-04510-z
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$${\text{COSNet}}_i$$: ComplexOme-Structural Network Interpreter used to study spatial enrichment in metazoan ribosomes

Abstract: Background Upon environmental stimuli, ribosomes are surmised to undergo compositional rearrangements due to abundance changes among proteins assembled into the complex, leading to modulated structural and functional characteristics. Here, we present the ComplexOme-Structural Network Interpreter ($${\text{COSNet}}_i$$ COSNet i ), a computational method to allow testing whether ribosomal prote… Show more

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Cited by 3 publications
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“…Seven ribosomal proteins were identified among the significantly stabilized targets. Spatial statistics were performed using a Cryo‐EM wheat 80S ribosome structure (Armache et al., 2010a; Armache et al., 2010b) following previously published procedures (https://github.com/MSeidelFed/COSNet_i) (Martinez‐Seidel, Hsieh, et al., 2021) and tuning parameters (Martinez‐Seidel, Beine‐Golovchuk, et al., 2021). Coherent ribosomal regions were obtained and Fisher's exact test was used to statistically inquire whether the significantly stabilized ribosomal proteins were constrained to specific ribosomal regions or randomly scattered in the complex.…”
Section: Methodsmentioning
confidence: 99%
“…Seven ribosomal proteins were identified among the significantly stabilized targets. Spatial statistics were performed using a Cryo‐EM wheat 80S ribosome structure (Armache et al., 2010a; Armache et al., 2010b) following previously published procedures (https://github.com/MSeidelFed/COSNet_i) (Martinez‐Seidel, Hsieh, et al., 2021) and tuning parameters (Martinez‐Seidel, Beine‐Golovchuk, et al., 2021). Coherent ribosomal regions were obtained and Fisher's exact test was used to statistically inquire whether the significantly stabilized ribosomal proteins were constrained to specific ribosomal regions or randomly scattered in the complex.…”
Section: Methodsmentioning
confidence: 99%