Texture and surface feature-mediated striking improvements on multiple direct compaction properties of Zingiberis Rhizoma extracted powder by coprocessing with nano-silica

Zhang, Yue; Li, Yiping; Wu, Fei; Yang, Hong; Shen, Lan; Lin, Xiao; Feng, Yi

doi:10.1016/j.ijpharm.2021.120703

Cited by 17 publications

(6 citation statements)

References 55 publications

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“…Due to its small size, silica has a large specific surface area (about 100–400 m 2 /g depending on grade) [ 132 , 133 ]. Thus, silica has abundant surface free energy and has the ability to physically adsorb onto the surface of surrounding materials.…”

Section: Siomentioning

confidence: 99%

“…In a recent published study, colloidal silica N20 was used as the unitary surface modifier to improve direct compaction properties of Zingiberis rhizoma extracted powder (ZR) by liquid dispersion [ 133 ]. The ratio of ZR to nano-silica separately was 1:0.25, 1:0.33, 1:0.41, and 1:0.5.…”

Section: Siomentioning

confidence: 99%

“…The higher viscosity and lower surface tension of the modifier liquid were conducive to enhance the bonding force of materials and contributed to modifier spread ability and wettability on the surface of core materials, thus, forming a more perfect core-shell structure. The applications of SiO 2 were summarized in Table 3 [ 14 , 25 , 33 , 34 , 35 , 51 , 53 , 133 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 ].…”

Section: Siomentioning

confidence: 99%

“…The mechanism of improved dissolution and drug loading could be summarized as follows: (i) the disordered reorganization and dispersion of drug crystals leads to a reduction in particle size of the drug loaded inside the porous mannitol to the nanometer scale; (ii) corresponding improvement in wettability and dispersibility of co-treated particles; (iii) the larger pore volume of porous mannitol is conducive to the entry and penetration of the dissolution medium and improves the contact area and contact rate of the medium, thus, improving the dissolution of the drug. The applications of MCC were summarized in Table 4 [ 64 , 133 , 154 , 165 , 166 , 171 , 172 ].…”

Section: Mannitolmentioning

confidence: 99%

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Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

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Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully manufactured into tablets using DC since most APIs lack adequate functional properties to meet DC requirements. The use of suitable modifiers and appropriate co-processing technologies can provide a promising approach for the preparation of composite particles with high functional properties. The purpose of this review is to provide an overview and classification of different modifiers and their multiple combinations that may improve API tableting properties or prepare composite excipients with appropriate co-processed technology, as well as discuss the corresponding modification mechanism. Moreover, it provides solutions for selecting appropriate modifiers and co-processing technologies to prepare composite particles with improved properties.

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Section: Siomentioning

confidence: 99%

Section: Siomentioning

confidence: 99%

Section: Siomentioning

confidence: 99%

Section: Mannitolmentioning

confidence: 99%

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Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

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“…Particle structure modification can efficiently enhance the functional properties of powders since the fundamental properties of powders are mainly determined by particle structures. 140 For example, porous particles are usually prepared to increase drug loading or improve the dissolution of drugs, and core−shell particles are designed to improve the flowability or compressibility. Currently, structure modification on particles are primarily performed using coprocessing technologies to have surface free energy, interfacial tension, electrostatic adsorption, capillary force, liquid bridge, van der Waals force, Gibbs free energy, etc., jointly to form the specific structure.…”

Section: Structure-oriented Ddss Designmentioning

confidence: 99%

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Xue

et al. 2023

Mol. Pharmaceutics

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Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and biological properties of APIs and excipients have been extensively studied for their contribution to DDS quality and effectiveness; however, the structural characteristics of DDSs have not been adequately explored. Structure pharmaceutics involves the study of the structure of DDSs, especially the three-dimensional (3D) structures, and its interaction with the physiological and pathological structure of organisms, possibly influencing their release kinetics and targeting abilities. A systematic overview of the structures of a variety of dosage forms, such as tablets, granules, pellets, microspheres, powders, and nanoparticles, is presented. Moreover, the influence of structures on the release and targeting capability of DDSs has also been discussed, especially the in vitro and in vivo release correlation and the structure-based organ- and tumor-targeting capabilities of particles with different structures. Additionally, an in-depth discussion is provided regarding the application of structural strategies in the DDSs design and evaluation. Furthermore, some of the most frequently used characterization techniques in structure pharmaceutics are briefly described along with their potential future applications.

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A Review on Research and Application of Expert Systems on Drug Formulation and Process Design

Du,

Zhang

2024

Exploring Computational Pharmaceutics ‐ AI and Modeling in Pharma 4.0

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Texture and surface feature-mediated striking improvements on multiple direct compaction properties of Zingiberis Rhizoma extracted powder by coprocessing with nano-silica

Cited by 17 publications

References 55 publications

Surface Modifiers on Composite Particles for Direct Compaction

Surface Modifiers on Composite Particles for Direct Compaction

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

A Review on Research and Application of Expert Systems on Drug Formulation and Process Design

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