With the increasing trend of aging population, knee and hip replacement surgery has been widely used as the main method to treat joint diseases. In this paper, the material selection and longterm maintenance strategy of knee and hip prosthesis are deeply studied. Firstly, by comparing the mechanical properties of metals, ceramics and other new materials, the importance of individualized material selection is put forward. Considering the patient's age, activity level and other factors, it is very important to choose suitable materials for the success of the operation. Secondly, the paper emphasizes the key of long-term maintenance after operation, including regular follow-up, imaging examination, material interface management and other strategies to ensure the long-term stability of joint prosthesis. In particular, the importance of anti-infection strategy in maintenance is emphasized, and the risk of infection is reduced through measures such as preoperative infection risk assessment, intraoperative aseptic operation and preventive antibiotic application. Scientific and reasonable material selection and long-term maintenance strategy are expected to improve the success rate of joint prosthesis surgery and bring longer-term health benefits to patients.