TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2-b][1,2,4]triazine and Pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole Derivatives

Abstract

An efficient high-pressure-assisted trifluoroacetic acid-catalyzed protocol for synthesizing unreported novel pyrido-[1,2-b][1,2,4]triazine and pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole derivatives has been established. This strategy includes the condensation reactions of various 1-amino-2-imino-4-arylpyridine-3-carbonitrile derivatives with indoline-2,3-dione (isatin) derivatives and α-keto acids such as pyruvic acid and phenylglyoxylic acid. This strategy includes utilizing the Q-tube reactor as an efficient and safe tool to conduct these reactions under highpressure conditions. In addition, trifluoroacetic acid was used to induce this transformation. In this research, conducting the targeted reactions under high pressure using the Q-tube reactor was found to be superb in comparison to that under the traditional refluxing conditions. X-ray single-crystal analysis was utilized in this study to authenticate the structure of the synthesized products.

The Q-Tube-Assisted Green Sustainable Synthesis of Fused Azines: New Synthetic Opportunities via Innovative Green Technology

“…Bearing in mind all of the above and inspired by our previous work utilizing green chemistry tools for the synthesis of biologically active heterocyclic compounds [17][18][19][20] and the recently published work on utilizing the high-pressure Q-tube [21][22][23][24][25], we are boiling point is exceeded during the reaction process. The Arrhenius equation states that reaction rates double when the temperature is raised by 10 °C (Equation (1)).…”

“…Bearing in mind all of the above and inspired by our previous work utilizing green chemistry tools for the synthesis of biologically active heterocyclic compounds [17][18][19][20] and the recently published work on utilizing the high-pressure Q-tube [21][22][23][24][25], we are On the other hand, for a plethora of organic reactions, layered double hydroxides [LDHs] can serve as catalysts [12][13][14][15]. The hydroxyl groups in Mg(OH) 2 [brucite] coordinate octahedrally with some Mg 2+ cations, similar to that in brucite, whereas some Al 3+ ions are substituted with trivalent ions.…”

“…Bearing in mind all of the above and inspired by our previous work utilizing green chemistry tools for the synthesis of biologically active heterocyclic compounds [17][18][19][20] and the recently published work on utilizing the high-pressure Q-tube [21][22][23][24][25], we are encouraged to highlight and confirm the success of the Q-tube system in organic synthesis as economic tools that save energy. In this study, we tested the Q-tube for the reaction of chalcones with nitrogen nucleophils.…”

Efficient synthesis of new indenopyridotriazine [4.3.3]propellanes and spiroindenopyridotriazine-4H-pyran derivatives

“…9 Manifold and varied syntheses of these systems are well documented in the literature. [10][11][12] Pyridotriazine moieties are commonly synthesized via heterocyclization reaction between 1,6-diaminopyridones and bifunctional electrophiles. As an unsymmetrical diamine, 1,6-diaminopyridone is a very active substrate for building diverse heterocyclic systems.…”

High-Pressure Metal-Free Catalyzed One-Pot Two-Component Synthetic Approach for New 5-Arylazopyrazolo[3,4-b]Pyridine Derivatives

“…The Q-tube strategy was recommended as the technique of preference for the cleanest, shortest, and most effective preparation of the heterocyclic compounds under study [ 22 ]. In other respects, the coupling Q-tube-assisted approach with the one-pot multicomponent reactions (MCRs) strategy is considered to be one of the most advantageous protocols for achieving step efficiency and atom economy [ 19 , 23 , 24 , 25 , 26 ]. In this study, the coupling of the Q-tube-mediated protocol with the two-component reaction (MCR) strategy can be investigated to provide universal access to a series of unreported 5-arylazopyrazolo[3,4- b ]pyridines with superior reaction profiles and higher rates and approximately quantitative yields.…”