TFOS Lifestyle: Impact of contact lenses on the ocular surface

Evaluating GlicoPro Tear Substitute Derived from Helix aspersa Snail Mucus in Alleviating Severe Dry Eye Disease: A First-in-Human Study on Corneal Esthesiometry Recovery and Ocular Pain Relief

“…; (2) DED diagnosis according to DEWS II [ 6 ]; and one of the following conditions: (2.1) ocular surface disease index (OSDI) score > 33 points; (2.2) non-invasive break-up time (NIBUT) < 10 s; and (3) meibomian gland dysfunction (MGD) according to the international workshop on MGD [ 17 ], meeting one of the following conditions: (3.1) eyelid margin or mucocutaneous junction irregularities; (3.2) eyelid margin vascularity; (3.3) capped or plugged Meibomian gland orifices; (3.4) atrophy of Meibomian glands; and (3.5) meibum quality and quantity decrease. The exclusion criteria included (1) degenerative diseases such as Parkinson’s disease or multiple sclerosis; (2) corneal infections and corneal dystrophies; (3) contact lens wearers; (4) active ocular allergy; (5) pregnant or lactating; and (6) patients who did not understand informed consent [ 18 , 19 , 20 ].…”

Bioinspired Lubricity from Surface Gel Layers

“…These aqueous networks, composed of heavily glycosylated polypeptides (mucins), are continuously secreted by moist epithelial cells lining all external interfaces in the body (e.g., the eye, respiratory tract, gastrointestinal tract, reproductive tract, pleural cavity, organ sheaths, etc. ). − Mucin gels serve multiple functions, including physical barriers to pathogens and debris, − moisture-retaining layers, − and mechanical fuses capable of supporting loads at rest, yet shear-thinning and rapidly rehealing in response to low shear stress. − In the eye, mucin gels are secreted by opposing corneal and conjunctival epithelium that together create a gel-spanning network across the ocular tear film with shallow gradients of mucin emanating from each tissue layer. − Biomedical devices and implants placed directly against delicate mucin gels to improve form or function can disrupt natural biological lubrication mechanisms and lead to discomfort (e.g., contact lens-induced dry eye − ). Over the past decade, prevalent design strategies to reduce device-induced discomfort have involved weak interfacial layers inspired by mucin gels.…”

A water transfer printing method for contact lenses surface 2D MXene modification to resist bacterial infection and inflammation

“…On the basis of material composition, CL can be classified as either rigid gas-permeable lenses fabricated from silicone and fluorine polymers or soft hydrogel and silicone hydrogel lenses. Approximately 140 million patients worldwide choose to wear CL instead of frame glasses each year because of their advantages, such as aesthetics, ease of movement, and low cost ( 1 ). In the context of the increasingly widespread use of electronic products, myopia in adolescents has shown a high incidence trend in recent years ( 2 ).…”