TFOS Lifestyle: Impact of nutrition on the ocular surface

Markoulli, Maria; Arcot, Jayashree; Ahmad, Sumayya; Arita, Reiko; Benítez-del-Castillo, J.M.; Caffery, Barbara; Downie, Laura E.; Edwards, Katie; Flanagan, Judith; Labétoulle, Marc; Misra, Stuti; Mrugacz, Małgorzata; Singh, Sumeer; Sheppard, John D.; Vehof, Jelle; Versura, Piera; Willcox, Mark; Ziemanski, Jillian F.; Wolffsohn, James S.

doi:10.1016/j.jtos.2023.04.003

Cited by 24 publications

(3 citation statements)

References 586 publications

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“…Tear uid lipids are concentrated in the outermost and aqueous layers and are responsible for lubricating blinks and preventing evaporation of the aqueous layer 95 . External exposures, such as exposures from poor air quality 96 , tobacco smoking 97 , and screen use 98 , and internal exposures, such as exposures from the gut microbiota 99 and aging 100 , have been associated to changes in the physical properties of the tear uid lipid layer.…”

Section: Biological Markers Of Exposure In the Tear Fluidmentioning

confidence: 99%

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

Amini,

Okeme

2023

Preprint

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Purpose: Exposures to hazardous chemicals have been linked to many detrimental health effects. It is critical to have effective biomonitoring methods to measure the levels of these chemicals in humans to better evaluate key environmental exposures that increase the risk of chronic disease and death. Traditional biomonitoring utilizing blood and urine is limited due to the specialized skills and invasiveness of collecting these fluid samples. The systematic review focuses on the tear fluid, which is largely under-researched, as promising alternative to these traditional fluids. The objective is to evaluate the practicability of using human tear fluid for biomonitoring environmental exposures, highlighting potential pitfalls and opportunities. Recent finding: Tear fluid biomonitoring represents a promising method for assessing exposures. Tear fluid uniquely interfaces with the external environment at the air-tear interface, providing a surface for airborne chemicals to diffuse into the ocular environment and interact with biomolecules. Tear fluid also contains molecules from the internal environment that have travelled from the blood to tears by crossing the blood-tear barrier. Our review shows that tear fluid can be used to identify hazardous chemicals from the external and environment environments and to differentiate between different exposure groups. Summary: The review provides a critical analysis of the current state of knowledge in tear-based biomonitoring and draws attention to the promise of using the method for noninvasively increasing access to exposure assessment. The method will become acceptable for routine use as more individual and inter lab studies focus on broadly identifying and quantify exposure markers in tears, understanding factors that influence reliability of the method and standardizing the tear fluid method.

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Section: Biological Markers Of Exposure In the Tear Fluidmentioning

confidence: 99%

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

Amini,

Okeme

2023

Preprint

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“…Epidemiological studies have investigated the potential link between meat and fish consumption and cancer risk, including colorectal, breast, prostate, and pancreatic cancer. Some studies show an increased risk, while others find no significant link or preventive benefit [116]. Epidemiological studies have linked higher consumption of red and processed meat to an increased risk of colorectal cancer and colon cancer.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Potential mutagenicity in Meat and Fish: An Outcome of High Heat Cooking

Tanveer,

Kanwal,

Rafeeq

et al. 2023

Preprint

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Being a great source of protein, B-vitamins and minerals, meat and fish are staple foods in many cultures. However, cooking at high temperatures can produce chemicals associated with an increased risk of developing cancer. This review investigates the possible carcinogenic activity of chemicals formed during the cooking of meat and fish including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and advanced glycation end products (AGEs). High-temperature cooking methods for meat, including grilling or frying, result in the formation of HCAs. Meat that has been smoked, grilled, or cooked over an open flame produces PAHs whereas, dry heat methods including roasting, grilling, and frying results in formation of AGEs. In vitro studies have shown that these compounds can damage DNA, cause mutations, and promote the growth of cancer cells. Research shows that thoroughly cooked meat increases the risk of cancer, particularly colorectal, pancreatic, and prostate cancer. Alternative cooking techniques, marinades, and incorporating fruits and vegetables can help to mitigate this risk. For determining the efficacy of these measures, additional studies are required. For the purpose of lowering the potential carcinogenic activity of chemicals formed during the cooking of meat and fish, mitigation techniques must be understood and put into practice. Cancer can be avoided by informing people about the dangers of eating meat and fish that have been cooked at high temperatures and by encouraging better diets and cooking styles. In order to lessen the possible health concerns related to the eating of meat and fish, further studies are required.

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“…Recent research highlights the significant roles of nutritional deficiencies ( Castrejón-Morales et al, 2020 ; Chakraborty and Chandra, 2021 ; Jain et al, 2022 ; Markoulli et al, 2023 ), inflammation ( Wu et al, 2024 ), and oxidative stress ( Li et al, 2022a ) in DED’s pathogenesis. With the rising awareness of oxidative stress and its impact on visual function, many Researchers are exploring the potential benefits of antioxidant therapy through nutrient supplementation.…”

Section: Introductionmentioning

confidence: 99%

Recommendations for nutritional supplements for dry eye disease: current advances

Cong,

Zhang,

Han

et al. 2024

Front. Pharmacol.

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Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact of oral nutritional supplements, varying in composition and dosage, on the symptoms of DED. The main components of these supplements include fish oils (Omega-3 fatty acids), vitamins, trace elements, and phytochemical extracts. Beyond these well-known nutrients, it is necessary to explore whether novel nutrients might contribute to more effective DED management. This review provides a comprehensive update on the therapeutic potential of nutrients and presents new perspectives for combination supplements in DED treatment.

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TFOS Lifestyle: Impact of nutrition on the ocular surface

Cited by 24 publications

References 586 publications

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures

Potential mutagenicity in Meat and Fish: An Outcome of High Heat Cooking

Recommendations for nutritional supplements for dry eye disease: current advances

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