TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma.

Li, Zhigang; Shimada, Yutaka; Uchida, Satoshi; Maeda, Masato; Kawabe, Akira; Mori, Akira; Itami, Atsushi; Kano, Masato; Watanabe, Go; Imamura, Masayuki

doi:10.3892/ijo.17.3.453

Cited by 40 publications

(41 citation statements)

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“…Increased proliferative rates and poor prognosis of carcinomas in vivo are also correlated with increased expression of the EGFR (Baselga et al, 1996;Schmidt-Ullrich et al, 1992;Putz et al, 1999). MAPK signaling has also been linked to increased expression of growth factors such as VEGF (Pages et al, 2000;Rak et al, 2000;Li et al, 2000). Growth factors such as VEGF and TGFa, in addition to a growth promoting role in vitro, may also play an important role in the development of tumors in vivo due to their abilities in the promotion of angiogenesis (Slevin et al, 2000;Hossain et al, 2000;Mazure et al, 1997;Zundel et al, 2000;Pages et al, 2000;Rak et al, 2000;Li et al, 2000;Minet et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…MAPK signaling has also been linked to increased expression of growth factors such as VEGF (Pages et al, 2000;Rak et al, 2000;Li et al, 2000). Growth factors such as VEGF and TGFa, in addition to a growth promoting role in vitro, may also play an important role in the development of tumors in vivo due to their abilities in the promotion of angiogenesis (Slevin et al, 2000;Hossain et al, 2000;Mazure et al, 1997;Zundel et al, 2000;Pages et al, 2000;Rak et al, 2000;Li et al, 2000;Minet et al, 1999). Collectively, these ®ndings argue that radiation may have a self-limiting e ect on its toxicity via increased activity of EGFR and downstream signaling modules such as the MAPK pathway.…”

Section: Introductionmentioning

confidence: 99%

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Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

et al. 2001

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

et al. 2001

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“…26 Similarly, expression of angiogenic factors such as TGF-␣, PD-ECGF and bFGF by esophageal squamous carcinoma cells is associated with angiogenesis and metastasis. 28 Thus, angiogenic factors produced by carcinoma cells may be involved in the angiogenesis of esophageal carcinoma; however, little is known about the role of macrophages in angiogenesis of esophageal carcinoma.…”

mentioning

confidence: 99%

Monocyte chemoattractant protein‐1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas

Ohta

Kitadai

Tanaka

et al. 2002

Intl Journal of Cancer

141

109

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“…8 bFGF plays a critical role in physiologic and pathologic angiogenesis, including tumor angiogenesis. 9,10 It exerts its functions by direct action, 11 by inducing vascular endothelial growth factor (VEGF) synthesis, 12 or by potentiating VEGF activity. 13,14 Platelet-derived growth factor (PDGF) is a growth factor known to be active on ECs.…”

Section: Introductionmentioning

confidence: 99%

Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its α receptor

Marchis

Ribatti

Giampietri

et al. 2002

Blood

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Basic fibroblast growth factor (bFGF) and platelet-derived growth factor-BB (PDGF-BB) modulate vascular wall cell function in vitro and angiogenesis in vivo. The aim of the current study was to determine how bovine aorta endothelial cells (BAECs) respond to the simultaneous exposure to PDGF-BB and bFGF. It was found that bFGF-dependent BAEC migration, proliferation, and differentiation into tubelike structures on reconstituted extracellular matrix (Matrigel) were inhibited by PDGF-BB. The role played by PDGF receptor ␣ (PDGF-R␣) was investigated by selective stimulation with PDGF-AA, by blocking PDGF-BB-binding to PDGF-R␣ with neomycin, or by transfecting cells with dominant-negative forms of the receptors to selectively impair either PDGF-R␣ or PDGF-R␤ function. In all cases, PDGF-R␣ impairment abolished the inhibitory effect of PDGF-BB on bFGF-directed BAEC migration. In addition, PDGF-R␣ phosphorylation was increased in the presence of bFGF and PDGF, as compared to PDGF alone, whereas mitogen-activated protein kinase phosphorylation was decreased in the presence of PDGF-BB and bFGF compared with bFGF alone. In vivo experiments showed that PDGF-BB and PDGF-AA inhibited bFGF-induced angiogenesis in vivo in the chick embryo chorioallantoic membrane assay and that PDGF-BB inhibited bFGF-induced angiogenesis in Matrigel plugs injected subcutaneously in CD1 mice. Taken IntroductionThe endothelial layer represents a physical and chemical barrier between the vessel lumen and the underlying tissues. Endothelial cells (ECs) exert a variety of functions and modulate underlying smooth muscle cells by releasing molecules with vasoactive and growth-regulatory properties. 1 Endothelial cells present an active replication phenotype in vitro, but in vivo they are quiescent. 2 The different expression of membrane-bound receptors 3,4 and the in vivo action of specific inhibitors 5-7 may account, at least in part, for the different replication pattern observed.Basic fibroblast growth factor (bFGF) is a potent EC growth factor; it is known to induce a proangiogenic phenotype in ECs and is released under acidosis conditions that induce EC protection from apoptosis. 8 bFGF plays a critical role in physiologic and pathologic angiogenesis, including tumor angiogenesis. 9,10 It exerts its functions by direct action, 11 by inducing vascular endothelial growth factor (VEGF) synthesis, 12 or by potentiating VEGF activity. 13,14 Platelet-derived growth factor (PDGF) is a growth factor known to be active on ECs. Three PDGF isoforms have been identified as disulfide-linked dimers, namely PDGF-AA, PDGF-BB, and PDGF-AB, expressed by ECs under various conditions. 15-19 They interact with different affinity with 2 tyrosine-kinase receptors, PDGF-R␣ and PDGF-R␤, which are expressed on ECs in normal 4,20-22 and in pathologic conditions. [23][24][25][26] Recently, PDGF-C and PDGF-D isoforms were also identified. 27,28 PDGF isoforms are reported to exert mitogenic and chemotactic action on EC, although PDGF-AA appears to be less potent or inactive...

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TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma.

Cited by 40 publications

References 0 publications

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

Monocyte chemoattractant protein‐1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas

Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its α receptor

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