2012
DOI: 10.1074/jbc.m112.351601
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TGF-β-activated Kinase 1 (TAK1) and Apoptosis Signal-regulating Kinase 1 (ASK1) Interact with the Promyogenic Receptor Cdo to Promote Myogenic Differentiation via Activation of p38MAPK Pathway

Abstract: Background: p38MAPK plays an essential role in myoblast differentiation. Results: TAK1 and ASK1 interact with Cdo and JLP to promote myogenesis. Conclusion: TAK1 and ASK1 act as MAP3Ks to activate p38MAPK in Cdo-mediated myogenesis. Significance: This might be the first report to identify MAP3Ks in Cdo-mediated myogenesis.

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Cited by 32 publications
(30 citation statements)
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“…Next, we performed the gene-annotation enrichment analysis to find functional annotation clustering with the DAVID informatics tool (DAVID Bioinformatics Resources 6.8, National Institute of Allergy and Infectious Diseases/NIH) based on Gene Ontology (GO). Using the 446 differentially regulated genes, we identified nine biological GO terms such as "cell adhesion," "regulation of transferase activity," and "regulation of cell motion," consistent with the proposed role of Cdon (31)(32)(33) (Fig. 3 B and C and SI Appendix, Table 2).…”
Section: Cdon-deficient Hearts Exhibit Alterations In Gene Expressionsupporting
confidence: 59%
“…Next, we performed the gene-annotation enrichment analysis to find functional annotation clustering with the DAVID informatics tool (DAVID Bioinformatics Resources 6.8, National Institute of Allergy and Infectious Diseases/NIH) based on Gene Ontology (GO). Using the 446 differentially regulated genes, we identified nine biological GO terms such as "cell adhesion," "regulation of transferase activity," and "regulation of cell motion," consistent with the proposed role of Cdon (31)(32)(33) (Fig. 3 B and C and SI Appendix, Table 2).…”
Section: Cdon-deficient Hearts Exhibit Alterations In Gene Expressionsupporting
confidence: 59%
“…During myoblast differentiation, the cell surface receptor Cdo binds scaffold protein JLP and subsequently recruits MKK3/6 and p38MAPK (18,(35)(36)(37). In this Cdo-mediated p38MAPK activation, TAK1 and ASK1 function as MAP3Ks to promote myogenic differentiation (38). Besides phosphorylation, the spatial regulation of p38MAPK and its scaffold proteins is critical for performing their functions (39).…”
Section: Discussionmentioning
confidence: 99%
“…Immunoblot analysis was performed as previously described 30,31 . Briefly, the brain tissues were lysed in RIPA buffer (iNtRON Biotechnology, Korea) containing complete protease inhibitor cocktail (Roche), followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.…”
Section: Immunofluorescence Staining Immunoblotting and Rna Analysismentioning
confidence: 99%