TGF-β at the crossroads of multiple prognosis in breast cancer, and beyond

Shukla, Nirali; Naik, Ankit; Moryani, Kamlesh; Soni, Molisha; Shah, Jigna S; Dave, Heena

doi:10.1016/j.lfs.2022.121011

Cited by 8 publications

(5 citation statements)

References 177 publications

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“…Multiple intercellular interactions were stronger in the high SGS group vs. the low group ( Figure 5F ). Many signaling pathways, such as WNT, VEGF, and TGF-β, reported to be associated with the development of cancer [ 17 – 19 ], were found to be up-regulated in the high SGS group ( Figure 5G ). Cellular interactions in which the recipient cells are tumor epithelial cells were screened out.…”

Section: Resultsmentioning

confidence: 99%

“…These pathways have been reported to be associated with breast cancer malignancy [ 26 , 27 ]. At the single cell level, cell communication analysis also suggested that the signaling pathways such as WNT, VEGF, and TGF-β, which are widely known associated with tumor malignancy, were up-regulated in the high SGS group [ 17 – 19 ] NOTCH signaling has also been reported to be associated with the maintenance of stemness in breast cancer stem cells [ 20 ]. Our findings may be correlate with high tumor progression and metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Lin,

Feng,

Liu

et al. 2023

Aging

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Breast cancer (BC) is a heterogeneous disease characterized by significant differences in prognosis and therapy response. Numerous prognostic tools have been developed for breast cancer. Usually these tools are based on bulk RNA-sequencing (RNA-Seq) and ignore tumor heterogeneity. Consequently, the goal of this study was to construct a single-cell level tool for predicting the prognosis of BC patients. In this study, we constructed a stemness-risk gene score (SGS) model based on single-sample gene set enrichment analysis (ssGSEA). Patients were divided into two groups based on the median SGS. Patients with a high SGS scores had a significantly worse prognosis than those with a low SGS, and these groups exhibited differences in several tumor characteristics, such as immune infiltration, gene mutations, and copy number variants. Our results indicate that the SGS is a reliable tool for predicting prognosis and response to immunotherapy in BC patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Lin,

Feng,

Liu

et al. 2023

Aging

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“…In the breast cancer cells treated for 15s, the down-regulated genes were concentrated in the Wnt signaling pathway, indicating that low temperature plasma effectively inhibited the migration of cancer cells. Transforming growth factor β(TGF-β), as a pluripotent cytokine and multifunctional growth factor, plays an important role in the normal breast development and breast cancer [41]. After resveratrol was applied to MDA231 cells, it was found that resveratrol could reverse TGF-β1 and inhibit the migration of MDA231 cells [42].…”

Section: Kegg Pathway Enrichment Analysis Of Degsmentioning

confidence: 99%

Effect of low temperature plasma on the transcriptome of breast cancer cells

Liu,

Yan,

Liu

et al. 2024

Preprint

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Breast cancer is one of the most commonly diagnosed cancers in women, and due to the limitations of its therapeutic methods, new therapeutic method need to be developed. More and more evidences had shown the potential of low-temperature plasma (LTP) in cancer treatment. In this study, we investigated the inhibitory effect of LTP on the in vitro toxicity of breast cancer cells through the MTT assay, extracellular reactive oxygen species (ROS), and transcriptomics analysis. The results showed that under a certain treatment time, the cell viability was gradually decreased, and the extracellular ROS was gradually increased. In addition, the results of transcriptomics analysis showed that 1272 DEGs, 1573 DEGs, and 1272 DEGs were obtained in the 15s, 30s, and 45s treatment groups, respectively. DEGs were involved in MAPK signaling pathway, Fox O signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, chemical carcinogenesis-reactive oxygen species and mTOR Signaling pathway. In summary, our data suggested that LTP inhibited cell viability while inducing the activation of differentially expressed genes, representing a potential new therapy for breast cancer.

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“…In addition to the effects on the cell cycle, in breast cancer, TGF-β signaling has been found to be an important factor in cancer invasion and metastasis [ 107 ]. Researchers have shown in a mouse model that human epidermal growth factor receptor 2 (HER2) modulates TGF-β signaling through the AKT-mediated phosphorylation of Smad3, promoting cell migration and EMT of breast cancer cells [ 108 ].…”

Section: Main Textmentioning

confidence: 99%

TGF-β signaling: critical nexus of fibrogenesis and cancer

Giarratana,

Prendergast,

Salvatore

et al. 2024

J Transl Med

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The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. It functions through canonical SMAD-mediated processes and noncanonical pathways involving MAPK cascades, PI3K/AKT, Rho-like GTPases, and NF-κB signaling. This intricate signaling system is finely tuned by interactions between canonical and noncanonical pathways and plays key roles in both physiologic and pathologic conditions including tissue homeostasis, fibrosis, and cancer progression. TGF-β signaling is known to have paradoxical actions. Under normal physiologic conditions, TGF-β signaling promotes cell quiescence and apoptosis, acting as a tumor suppressor. In contrast, in pathological states such as inflammation and cancer, it triggers processes that facilitate cancer progression and tissue remodeling, thus promoting tumor development and fibrosis. Here, we detail the role that TGF-β plays in cancer and fibrosis and highlight the potential for future theranostics targeting this pathway.

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TGF-β at the crossroads of multiple prognosis in breast cancer, and beyond

Cited by 8 publications

References 177 publications

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Effect of low temperature plasma on the transcriptome of breast cancer cells

TGF-β signaling: critical nexus of fibrogenesis and cancer

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