2020
DOI: 10.1038/s41598-020-67325-7
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TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer

Abstract: Transforming growth factor-β (TGF-β) promotes tumor invasion and metastasis by inducing epithelialmesenchymal transition (EMT). EMT is often related with acquisition of stemness characteristics. The objective of this study was to determine whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer. A human normal lung epithelial cell line and four lung cancer cell lines were treated with TGF-β. Transcriptome analysis of BEAS-2B and A549 cells incubat… Show more

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Cited by 140 publications
(96 citation statements)
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“…Consistent observations have been made in breast cancer and prostate cancer, where SLUG degradation promotes the differentiation of breast cancer stem cells [Fraile et al, 2020], and the basal prostate cells that expressed SLUG exhibited a partial EMT phenotype and displayed increased stemness ability [Kahonouva et al, 2020]. The functional contribution of SLUG in vitro and/or in vivo enabling stemness is also observed in human epidermal progenitor cells [Mistry et al, 2014] as well as other cancers such as glioblastoma [Chesnelong et al, 2019], hepatocellular carcinoma [Tang et al, 2016;Sun et al, 2014], colorectal cancer [Kato et al, 2020], lung cancer [Kim et al, 2020] and squamous cell carcinomas [Yu et al, 2016;Moon et al, 2020]. Whether higher stemness is connected to a hybrid E/M phenotype in these cancers remains to be identified.…”
Section: Discussionsupporting
confidence: 63%
“…Consistent observations have been made in breast cancer and prostate cancer, where SLUG degradation promotes the differentiation of breast cancer stem cells [Fraile et al, 2020], and the basal prostate cells that expressed SLUG exhibited a partial EMT phenotype and displayed increased stemness ability [Kahonouva et al, 2020]. The functional contribution of SLUG in vitro and/or in vivo enabling stemness is also observed in human epidermal progenitor cells [Mistry et al, 2014] as well as other cancers such as glioblastoma [Chesnelong et al, 2019], hepatocellular carcinoma [Tang et al, 2016;Sun et al, 2014], colorectal cancer [Kato et al, 2020], lung cancer [Kim et al, 2020] and squamous cell carcinomas [Yu et al, 2016;Moon et al, 2020]. Whether higher stemness is connected to a hybrid E/M phenotype in these cancers remains to be identified.…”
Section: Discussionsupporting
confidence: 63%
“…Different molecular pathways act as upstream mediators of EMT in cancer progression. TGF-β signaling pathway is an EMT inducer in cancer cells and in this way, can provide chemoresistance [ 123 , 124 ]. PI3K/Akt signaling can also induce EMT in cancer cells, and its downregulation is associated with a decrease in EMT [ 125 , 126 ].…”
Section: Curcumin In Combination With Doxorubicinmentioning
confidence: 99%
“…A reorganization of the cytoskeleton, the formation of focal adhesions and of invadopodia, a gain in the expression of intermediate filaments such as vimentin and cytokeratin 14, and a gain in the expression of α-SMA (alpha−smooth muscle actin) are characteristic of the mesenchymal phenotype and are; therefore, considered mesenchymal markers during EMT [ 61 , 62 , 63 , 64 ]. Furthermore, the formation of actin stress fibers that provide the posterior–frontal polarity of the cells is also considered a marker of the mesenchymal phenotype [ 42 ].…”
Section: Epithelial–mesenchymal Transitionmentioning
confidence: 99%
“…On the other hand, the transmembrane glycoproteins of the mucin family, such as mucin 1, 4, and 16, are mesenchymal markers and their expression promotes an increase in migratory and invasive capacity [ 56 , 72 , 73 ]. Interestingly, the expression of CD44, another transmembrane glycoprotein, is also related to the stem and mesenchymal phenotype [ 47 , 64 ].…”
Section: Epithelial–mesenchymal Transitionmentioning
confidence: 99%