TGF-β S<scp>ignal</scp> T<scp>ransduction in</scp> O<scp>ro</scp>-<scp>facial</scp> H<scp>ealth and</scp> N<scp>on</scp>-<scp>malignant</scp> D<scp>isease </scp>(P<scp>art</scp> I)

Prime, Steven L.; Pring, Miranda; Davies, Malcolm; Paterson, Ian C.

doi:10.1177/154411130401500602

Cited by 57 publications

(51 citation statements)

References 177 publications

(182 reference statements)

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“…Although this growth factor pool may be used by the depositing cells themselves (10,11), it is possible that it also serves as a message for subsequent developmental processes governing the epithelial closure. Intriguingly, TGF-␤/BMP is the same signaling pathway associated with scar formation and scarless wound healing (12)(13)(14), and TGF-␤3 was demonstrated to mediate antiscarring effects. Important implications of TGF-␤ signaling (see Ref.…”

Section: Similarities Between Healing and Embryonic Developmentmentioning

confidence: 99%

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

et al. 2008

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When a sheep loses its tail, it cannot regenerate it in the manner of lizards. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field. (Pediatr Res 63: 502-512, 2008)

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Section: Similarities Between Healing and Embryonic Developmentmentioning

confidence: 99%

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

et al. 2008

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“…41 TGF-b1 is one of the key cytokines with pleiotropic properties that has both proinflammatory and anti-inflammatory features in the regulation of the inflammatory infiltrate. This cytokine is a chemoattractant for neutrophils, monocytes, mast cells and lymphocytes.…”

Section: 40mentioning

confidence: 99%

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Alhadlaq¹

2015

The Journal of Contemporary Dental Practice

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Background The analysis of gingival crevicular fluid (GCF) may be an acceptable way to examine the ongoing biochemical processes associated with bone turnover during orthodontic tooth movement. If it is possible to biologically monitor and predict the outcome of orthodontic forces, then the management of appliances could be based on individual tissue responses, and the effectiveness of the treatment could be improved. Methodology A literature search was carried out in major databases, such as medline, EMBASE, cochrane library, web of science, google scholar and scopus for relevant studies. Publications in English between 2000 and 2014 which estimated GCF markers as indicators of orthodontic tooth movement were included. Results The list of biomarkers available to date was compiled and presented in table format. Each biomarker is discussed separately based on the available evidence. Conclusion Several sensitive GCF markers are available to detect the biomechanical changes occurring during orthodontic tooth movement. Further focused research might help to analyze the sensitivity and reliability of these indicators, which in turn can lead to the development of chairside tests to assess the outcome of orthodontic therapy. How to cite this article Alhadlaq AM. Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review. J Contemp Dent Pract 2015;16(7):578-587.

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“…Our results confirm that increased gingival inflammation is associated with high levels of TGF-isoforms. It is well known that TGF-is one of several cytokines able to regulate inflammation and immune responses and the fact that TGF-mediates leukocyte recruitment, adhesion and activation suggests that it play a key role in the host response to bacterial and immunological insults (Prime et al, 2004), even there is not a clear evidence for its role in the pathogenesis of the periodontal disease. But TGF-has also a marked effect on ECM homeostasis, being an important mediator of fibroblast proliferation and ECM synthesis.…”

Section: B) Transforming Growth Factor-β (Tgf-β)mentioning

confidence: 99%

Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

Pisoschi¹,

Stănciulescu²,

Banita³

2012

Pathogenesis and Treatment of Periodontitis

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TGF-β Signal Transduction in Oro-facial Health and Non-malignant Disease (Part I)

Cited by 57 publications

References 177 publications

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

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