2020
DOI: 10.1101/2020.09.09.20191338
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TGF-β1 in extracellular vesicles from HIV-infected plasma and macrophages linked to cardiopulmonary dysfunction

Abstract: Rationale: Extracellular vesicles (EVs) have emerged as important mediators in cell-cell communication and disease pathogenesis; however, their relevance in pulmonary hypertension (PH) secondary to HIV infection is yet to be explored. Objective: To examine the role of circulating small EVs and monocyte-derived macrophage (MDM) EVs in the development of HIV-associated PH Methods: EVs isolated from plasma of HIV-infected drug users and non-users with/without PH and from supernatants of HIV-infected MDMs treate… Show more

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“…Extracellular vesicles (EVs) are small bi-layered membrane bodies released from all cell types and can serve as a vehicle for transferring proteins, coding and non-coding RNAs, lipids, and metabolites between cells. EVs released by HIV-infected monocyte-derived macrophages are reported to potentiate pulmonary vascular endothelial injury and smooth muscle proliferation 85 , leading to the development of cardiovascular dysfunction 86 . Higher numbers of TGF- β -linked extracellular vesicles were reported in the plasma of HIV-PAH patients compared to uninfected and HIV patients without PAH.…”
Section: Risk Factors That Complicate Hiv-phmentioning
confidence: 99%
“…Extracellular vesicles (EVs) are small bi-layered membrane bodies released from all cell types and can serve as a vehicle for transferring proteins, coding and non-coding RNAs, lipids, and metabolites between cells. EVs released by HIV-infected monocyte-derived macrophages are reported to potentiate pulmonary vascular endothelial injury and smooth muscle proliferation 85 , leading to the development of cardiovascular dysfunction 86 . Higher numbers of TGF- β -linked extracellular vesicles were reported in the plasma of HIV-PAH patients compared to uninfected and HIV patients without PAH.…”
Section: Risk Factors That Complicate Hiv-phmentioning
confidence: 99%