TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Tang, Yi; Wu, Xiangwei; Lei, Weiqi; Pang, Lijuan; Wan, Chao; Shi, Zhenqi; Zhao, Ling; Nagy, Tim R.; Peng, Xinyu; Hu, Junbo; Xu, Feng; Hul, Wim Van; Wan, Mei; Cao, Xu

doi:10.1038/nm.1979

Cited by 1,029 publications

(990 citation statements)

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“…Mice carrying a Camurati -Engelmann disease-derived mutation in the Tgfb1 gene had a high level of prematurely active TGF-1 in the bone marrow microenvironment and displayed the progressive diaphyseal dysplasia seen in the human disease. 17 These findings indicate that TGF-1 promotes the migration of osteoprogenitors to the resorbed bone surface where this osteoblast differentiation is induced.…”

Section: Bone Matrix-derived Coupling Factorsmentioning

confidence: 87%

“…Mice lacking TGF-1 exhibited a significant decrease in the osteoblast number on the bone surface, but an abnormal accumulation of osteoblasts in the marrow space. 17 A mutation in the Tgfb1 gene has been identified in patients with a skeleton remodeling disorder, CamuratiEngelmann disease. Mice carrying a Camurati -Engelmann disease-derived mutation in the Tgfb1 gene had a high level of prematurely active TGF-1 in the bone marrow microenvironment and displayed the progressive diaphyseal dysplasia seen in the human disease.…”

Section: Bone Matrix-derived Coupling Factorsmentioning

confidence: 99%

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Bone cell communication factors and Semaphorins

Negishi-Koga

Takayanagi

2012

BoneKEy Reports

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-6396/12 www.nature.com/bonekey IntroductionThe bony skeleton enables various crucial processes, such as locomotive activity, the storage of calcium and the harboring of hematopoietic stem cells. Bone is a dynamic organ that is continuously being broken down by osteoclasts and subsequently rebuilt with new bone by osteoblasts throughout the course of one ' s adult life. These activities occur in response to various hormones, cytokines, chemokines and biomechanical external stimuli. 1,2 This process, called bone remodeling, is a prerequisite for the normal bone homeostasis that maintains both bone quality and strength. 2 An imbalance of bone resorption and formation is often central to metabolic bone diseases in humans and animals. For example, excessive resorption by osteoclasts results in pathological bone destruction, as seen in osteoporosis, autoimmune arthritis, Paget ' s disease, periodontitis and bone tumors. 1,3,4 Therefore, bone remodeling must be regulated both temporally and spatially so that the aged or damaged bone is replaced by an essentially equivalent amount of new bone. 1,5,6 The bone remodeling is carried out within the temporary anatomic structures, so-called basic multicellular unit (BMU), which consists of a group of osteoclasts in front forming the cutting cone and a group of osteoblasts behind forming the closing cone, by associating with blood supply and the peripheral innervation. 7,8 The bone remodeling is a cycle consisting of three phases: ' initiation ' of bone resorption by osteoclasts, the ' transition ' from resorption to new bone formation (also well known as a ' reversal ' period) and the ' bone formation ' ( Figure 1 ). 6,9 The entire process is achieved by the coordinated actions of osteoclasts, osteoblasts and other osteoblast lineage cells, including bone-lining cells and osteocytes. The most obvious example is the osteoclastogenesis regulatory system by receptor activator of nuclear-B ligand (RANKL) and its decoy receptor osteoprotegerin (OPG), which are produced by osteoblast lineage cells. However, key questions remain REVIEW Bone cell communication factors and SemaphorinsTakako Negishi-Koga 1 , 2 , 3 and Hiroshi Takayanagi 1 , 2 , 3 , 4 Bone tissue is continuously renewed throughout adult life by a process called ' remodeling ' , which involves a dynamic interplay among bone cells including osteoclasts, osteoblasts and osteocytes. For example, a tight coupling between bone resorption and formation is essential for the homeostasis of the skeletal system. Studies on the coupling mechanism in physiological and pathological settings have revealed that osteoclasts or osteoclastic bone resorption promote bone formation through the production of diverse coupling factors. The classical coupling factors are the molecules that promote bone formation after resorption, but there may be distinct mechanisms at work in various phases of bone remodeling. A recent study revealed that the Semaphorin 4D expressed by osteoclasts inhibits bone formation, which represents a mechanism by which...

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Section: Bone Matrix-derived Coupling Factorsmentioning

confidence: 87%

Section: Bone Matrix-derived Coupling Factorsmentioning

confidence: 99%

Bone cell communication factors and Semaphorins

Negishi-Koga

Takayanagi

2012

BoneKEy Reports

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“…In particular, bone morphogenetic protein-2 (BMP-2), which belongs to the transforming growth factor β (TGF-β) superfamily, is applied in the field of dental and orthopedic implants because of its strong osteoinductive effect (Migliorini et al, 2016). In addition, TGF-β1 is known to regulate bone remodeling Tang et al, 2009). Vascular endothelial growth factors (VEGFs) stimulate the formation of new blood vessels and are used for vascular materials as well as for bone regeneration Yang et al, 2012).…”

Section: Components Of Multifunctional Biomaterials Coatingsmentioning

confidence: 99%

Multifunctional biomaterial coatings: synthetic challenges and biological activity

Pagel

Beck‐Sickinger

2017

Biological Chemistry

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A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of various combinations of bioactive, and bioinert components as well as of reporter molecules to improve cell-material contacts, prevent infections or to analyze biochemical events on the surface. However, specific immobilization and particular assembly of various active molecules are challenging. Herein, an overview of multifunctional coatings for biomaterials is given, focusing on synthetic strategies and the biological benefits by displaying several motifs.

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“…7) Transforming growth factor-beta (TGF-β) and bone morphogenetic protein (BMP) are embedded in the bone matrix by osteoblasts via the bone-forming process. They function as differentiating and activating factors of the osteoblasts, and promote bone formation by means of such cells when those factors are released from the bone matrix 43,44) . As previously described, bone resorption is promoted at the same time as bone formation at the initial stage of exercise, and remarkable results are obtained by exercise after short-term immobilization.…”

Section: Effects Of Mechanical Stress On Bone Structuresmentioning

confidence: 99%

Characteristics of bone structural changes by growth and mechanical stress in growing rats

Ohsako

Morita

Inoue

et al. 2014

JPFSM

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Cortical bone is porous in infants but compacts with growth. In that process, circumferential lamellae are formed on the endosteum (inner) side of cortical bone first, and also the periosteum (exterior) side, after that. A mature rat shows higher bone strength per unit area of the cortical bone, and this means that not only an increase in the bone mass, but also improvement of the bone structure contributes to enhancing the bone strength. External morphology of the bone hardly changes by immobilization, but the thickness of the cortical bone decreases, and disorder of the running direction of the blood vessels in the cortical bone also occurs. Bone formation and resorption are caused simultaneously at the early stage of an exercise period, and it is supposed that factors embedded in the bone matrix beforehand are released into bone marrow by exercise, differentiating and activating the osteoblasts. Thus, it is thought that bone adapted to mechanical stress is formed by repeating active remodeling in the growing period.

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TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Cited by 1,029 publications

References 56 publications

Bone cell communication factors and Semaphorins

Bone cell communication factors and Semaphorins

Multifunctional biomaterial coatings: synthetic challenges and biological activity

Characteristics of bone structural changes by growth and mechanical stress in growing rats

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