TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone

Mohamed, Amany Abdel-Rahman; Khater, Safaa I.; Metwally, Mohamed M.M.; Emran, Talha Bin; Nassan, Mohamed A.; El-Emam, Mahran M. Abd; Mostafa‐Hedeab, Gomaa; El‐Shetry, Eman S.

doi:10.1016/j.gene.2022.146293

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…O 3 has been used as a therapy against CDDP induced damage, improving function and augmenting antioxidant defenses. Thiobarbituric acid reactive substances (TBARS, an assay used to measure lipid peroxidation; [ 72 ]), as well as NAG and morphologic damage, displayed decreased values when treated with O 3 [ 73 , 74 , 75 ]. Protective effects, however, varied according to the administered O 3 concentration, given that the administration of 0.36 mg/kg might be therapeutic [ 60 ] or might not [ 75 ].…”

Section: Damage Models and O 3 Effectmentioning

confidence: 99%

“…Protective effects, however, varied according to the administered O 3 concentration, given that the administration of 0.36 mg/kg might be therapeutic [ 60 ] or might not [ 75 ]. On the other hand, 1.1 mg/kg always shows protective tendencies in CDDP-induced damage [ 73 , 74 , 75 ]. Higher concentrations, e.g., 1.8 mg/kg, might be protective [ 62 ].…”

Section: Damage Models and O 3 Effectmentioning

confidence: 99%

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The Protective Role of Ozone Therapy in Kidney Disease: A Review

Delgadillo-Valero

Hernández-Cruz

Pedraza-Chaverri

2023

Life

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Ozone (O3) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O3 induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxicity produced by low concentrations of O3, which enhance the cell’s suppliance of antioxidant properties without causing any further damage. Therapeutic concentrations vary extensively, although 50 µg/mL is commonly used in experimental and clinical procedures, given that augmented concentrations might work as germicides or cause endogenous damage. O3 therapy has been shown to be effective when applied before or after traumatic renal procedures, whether caused by ischemia, xenobiotics, chronic damage, or other models. In this review, we focus on discussing the role of O3 therapy in different models of kidney damage associated with fibrosis, apoptosis, oxidative stress, and inflammation. We integrate and report knowledge about O3 in renal therapy, debunking skepticism towards unconventional medicine, explaining its proven therapeutic properties, and thus providing background for its use in further research as well as in clinical settings.

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Section: Damage Models and O 3 Effectmentioning

confidence: 99%

Section: Damage Models and O 3 Effectmentioning

confidence: 99%

The Protective Role of Ozone Therapy in Kidney Disease: A Review

Delgadillo-Valero

Hernández-Cruz

Pedraza-Chaverri

2023

Life

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“…In a wider integrated analytical approach, already underlined by an illuminating pioneering study of metabonomics [171], techniques based on the coupling of gas chromatography/mass spectrometry, together with gene polymorphism analysis, methylome profile, transcriptomics, and so on, should be more extensively used in the future to clarify these aspects [34,[172][173][174][175][176][177][178][179]. In this sense, the data obtained by analyzing biological samples of plants [180] and mice [154] by means of a metabolomic approach are extremely promising.…”

Section: Assessment and Monitoring Of Efficacymentioning

confidence: 99%

The Biological and Molecular Action of Ozone and Its Derivatives: State-of-the-Art, Enhanced Scenarios, and Quality Insights

Travagli

Iorio

2023

IJMS

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The ultimate objective of this review is to encourage a multi-disciplinary and integrated methodological approach that, starting from the recognition of some current uncertainties, helps to deepen the molecular bases of ozone treatment effects on human and animal well-being and to optimize their performance in terms of reproducibility of results, quality, and safety. In fact, the common therapeutic treatments are normally documented by healthcare professionals’ prescriptions. The same applies to medicinal gases (whose uses are based on their pharmacological effects) that are intended for patients for treatment, diagnostic, or preventive purposes and that have been produced and inspected in accordance with good manufacturing practices and pharmacopoeia monographs. On the contrary, it is the responsibility of healthcare professionals, who thoughtfully choose to use ozone as a medicinal product, to achieve the following objectives: (i) to understand the molecular basis of the mechanism of action; (ii) to adjust the treatment according to the clinical responses obtained in accordance with the principles of precision medicine and personalized therapy; (iii) to ensure all quality standards.

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“…Additionally, the urinary excretion of a melatonin metabolite has been reported to be impaired in adults who were growth restricted prenatally or were born after 40 weeks of gestation, suggesting potential fetal programming of melatonin production that may impair melatonin related pathways in adulthood such as antioxidant defenses ( 135 ). Finally, direct nephrotoxicity from compounds such as cisplatin have been shown to be mitigated by melatonin given its antioxidant properties ( 137 ). The role of melatonin in neonatal oxidative stress related kidney injury has not been fully explored.…”

Section: Antioxidant Therapies Targeting Minimization Of Neonatal Kid...mentioning

confidence: 99%

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

et al. 2022

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Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.

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TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone

Cited by 14 publications

References 45 publications

The Protective Role of Ozone Therapy in Kidney Disease: A Review

The Protective Role of Ozone Therapy in Kidney Disease: A Review

The Biological and Molecular Action of Ozone and Its Derivatives: State-of-the-Art, Enhanced Scenarios, and Quality Insights

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

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