2017
DOI: 10.4314/ovj.v7i1.2
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TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus

Abstract: Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations. TGF-β1 was measured in serum of 12 dogs with … Show more

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Cited by 5 publications
(2 citation statements)
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“…Senile cataract in people with diabetes, which is called diabetes and cataracts in our study, is more common. The potential mechanisms for the pathogenesis of diabetes and cataracts are complicated and include the p38-MAPK signalling pathway [1,2] , polyol pathway [3] , and changes in in ammatory cytokines [4][5][6][7][8][9][10] . However, the precise mechanism of diabetes and cataracts remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Senile cataract in people with diabetes, which is called diabetes and cataracts in our study, is more common. The potential mechanisms for the pathogenesis of diabetes and cataracts are complicated and include the p38-MAPK signalling pathway [1,2] , polyol pathway [3] , and changes in in ammatory cytokines [4][5][6][7][8][9][10] . However, the precise mechanism of diabetes and cataracts remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…What's more common is senile cataract in people with diabetes, which is called diabetes and cataracts in our study. The potential mechanisms for the pathogenesis of diabetes and cataracts are complicated and include the p38-MAPK signalling pathway [1,2] , polyol pathway [3] , and changes in in ammatory cytokines [4][5][6][7][8][9][10] , and others. However, the precise mechanism of diabetes and cataracts remains unclear.…”
Section: Introductionmentioning
confidence: 99%