TH1/TH2 balance in murine and human pregnancy and effect of tau interferons

Chaouat, Gérard; Meliani, Aines Assal; Martal, J.; Hui, Lin; Diallo, Juliette Tranchot; Gras, Gabriel; Dormont, Dominique; Wegmann, T

doi:10.1016/s0143-4004(96)90100-9

Cited by 2 publications

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“…Various immunological mechanisms have been proposed (1)(2)(3)(4)(5)(6). Cytokines produced by type 2 helper T (Th2) cells, including IL-10 and tumor growth factor ␤ (TGF-␤), seem to be important for the maintenance of pregnancy through their immunosuppressive effects (2)(3)(4)(5). On the other hand, Th1 cytokines, such as IL-2, IFN-␥, and tumor necrosis factor ␣ (TNF-␣), induce abortion (1,6).…”

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confidence: 99%

Involvement of decidual Vα14 NKT cells in abortion

Ito

Karasawa

Kawano

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

161

135

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The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, V␣14 NKT cells expressing an invariant antigen receptor encoded by V␣14͞J␣281 and V␤7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with ␣-galactosylceramide (␣-GalCer), a specific ligand for V␣14 NKT cells. The ␣-GalCer-mediated abortion was not observed in V␣14 NKT-, IFN-␥-, tumor necrosis factor ␣-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated V␣14 NKT cells whose perforin-dependent killing and production of IFN-␥ and tumor necrosis factor ␣ were essential. The possible role of the decidual V␣14 NKT cells in the pathogenesis of abortion is discussed.

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mentioning

confidence: 99%

Involvement of decidual Vα14 NKT cells in abortion

Ito

Karasawa

Kawano

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

161

135

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“…Furthermore, reduced IL-10 blood levels are associated with human pregnancy disorders such as preeclampsia (Nath et al, 2020). While administration of IL-10 prevents naturally occurring fetal losses (Chaouat et al, 1995), its deletion can provoke spontaneous abortions in mice (Murphy et al, 2005). M-CSF has been shown to support placental function by affecting EVT invasion (Hamilton et al, 1998).…”

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confidence: 99%

The human placenta shapes the phenotype of decidual macrophages

Vondra

Hoebler

Lackner

et al. 2022

Preprint

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During human pregnancy, placenta-derived extravillous trophoblasts (EVT) invade the decidua and communicate with maternal immune cells. The decidua can be distinguished into basalis (decB) and parietalis (decP), the latter being unaffected by placentation. By defining a novel gating strategy, we report accumulation of myeloid cells in decB. We identified a decidua basalis-associated macrophage (decBAM) population with a differential transcriptome and secretome when compared to decidua parietalis-associated macrophages (decPAMs). decBAMs are CD11chi and efficient inducers of Tregs, proliferate in situ and secrete high levels of CXCL1, CXCL5, M-CSF, and IL-10. In contrast, decPAMs exert a dendritic cell-like, motile phenotype characterized by induced expression of HLA class II molecules, enhanced phagocytosis, and the ability to activate T cells. Strikingly, EVT-conditioned media are able to convert decPAMs into a decBAM phenotype. Cumulatively, these findings assign distinct macrophage phenotypes to decidual areas depending on placentation and further highlight a critical role for EVTs in the induction of pregnancy-tolerant macrophage polarization.

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TH1/TH2 balance in murine and human pregnancy and effect of tau interferons

Cited by 2 publications

References 0 publications

Involvement of decidual Vα14 NKT cells in abortion

Involvement of decidual Vα14 NKT cells in abortion

The human placenta shapes the phenotype of decidual macrophages

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