Th17/Regulatory T Cell Imbalance in Sepsis Patients with Multiple Organ Dysfunction Syndrome: Attenuated by High-volume Hemofiltration

Guo, JiGuang; Tao, Wu; Tang, Dan; Zhang, Jianbin

doi:10.5301/ijao.5000625

Cited by 38 publications

(53 citation statements)

References 16 publications

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“…However, the ratio of Th17 cells and Tregs impacts the outcome of inflammatory conditions associated with these immune cells including infections (Diller et al, 2016;Ma et al, 2015;Sehrawat and Rouse, 2017). For example, as described in previous section that Th17/Treg ratio during sepsis plays an important role in MODS observed during sepsis (Guo et al, 2017;Yu et al, 2015a). Immunometabolic pathways control the balance between Th17 and Tregs (Sun et al, 2017).…”

Section: Th17 Cell Immunometabolism During Homeostasis and Sepsismentioning

confidence: 98%

“…Thus, this decrease in Th17 cells proves detrimental to septic patients via promoting immunoparalysis/immunosuppression (Rendon and Choudhry, 2012). An association between imbalanced Th17 and regulatory T cells (Tregs) cell population during multi-organ dysfunction syndrome (MODS) including acute respiratory distress syndrome (ARDS) is also observed during sepsis (Guo et al, 2017;Yu et al, 2015a). The decreased Th17 immune response during sepsis increases the chance to developing fungal infections including Candida albicans (van de Veerdonk et al, 2012).…”

Section: Th17 Cells In Sepsismentioning

confidence: 99%

“…Targeting a glutamate-dependent metabolic pathway in inflammatory conditions associated with an imbalance between Th17 cell and Tregs may prove a novel therapeutic strategy to control an exaggerated inflammation (Sun et al, 2017). Sepsis and associated acute respiratory distress syndrome (ARDS) are also considered a situation of imbalance between Th17 and Tregs (Guo et al, 2017;Yu et al, 2015b). An injection of a Chinese herbal medicine called Xuebijing (XBJ) containing extracts from 5 herbs potentially improved the survival of animals subjected to polymicrobial sepsis and septic shock .…”

Section: Targeting T Cells/tregs and Their Immunometabolism In Sepsismentioning

confidence: 99%

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T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics

Kumar

2018

European Journal of Cell Biology

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Section: Th17 Cell Immunometabolism During Homeostasis and Sepsismentioning

confidence: 98%

Section: Th17 Cells In Sepsismentioning

confidence: 99%

Section: Targeting T Cells/tregs and Their Immunometabolism In Sepsismentioning

confidence: 99%

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T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics

Kumar

2018

European Journal of Cell Biology

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“…CD4+ and CD8+ expression levels, and CD4+/CD8+ ratios of the three groups of subjects were compared. Patients with mild and severe sepsis were evaluated for Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) (Sadaka et al 2017) and Multiple Organ Dysfunction Score (MODS) (Guo et al 2017). The correlation between serum HMGB1 expression and APACHE II and MODS scores was analyzed.…”

Section: Measurement Outcomesmentioning

confidence: 99%

Expression and significance of HMGB1 in patients with sepsis and effects on prognosis

et al. 2020

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This study explored the expression of high mobility group box 1 protein (HMGB1) expression in patients with sepsis and its effects on immune function and prognosis. Patients with sepsis (n = 112) were divided into the mild group (MG, n = 59) and severe group (SG, n = 53) according to the disease severity of sepsis. Fifty healthy people who came to our hospital for physical examination at the same time served as the control group (CG). Serum HMGB1, CD4+, and CD8+ expression levels and CD4+/CD8+ ratios were compared between the three groups. The correlation between serum HMGB1 expression, APACHE II score, and MODS score was analyzed. Serum HMGB1 and CD8+ expressions were lower in the CG group than the values in the MG and SG groups, whereas the CD4+ expression and CD4+/CD8+ ratio were higher. Serum HMGB1 expression in sepsis patients was positively correlated with the APACHEII and MODS scores. In addition, the 28-day survival rate of the MG was higher than that of the SG. HMGB1 was highly expressed in the serum of patients with sepsis. HMGB1 expression was positively associated with the severity of sepsis. In addition, HMGB1 was closely related to the immune function and prognosis of patients with sepsis. ARTICLE HISTORY

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“…The imbalance ratio of Treg and helper T lymphocytes 17 (Th17) will affect the progress of interactions and is related to the occurrence and development of sepsis 21 and other diseases 22,23 .The results of flow cytometry manifested a high ratio of Th17 /Treg in sepsis murine.Both ETDCs and miR155 -/-ETDCs infusion displayed a ability to attenuate Th17/Treg ratio while the Th17/Treg ratio was lowest in the miR155 -/-ETDCs treatment group.…”

Section: Infusion Of Etdcs and Mir155 -/-Etdcs Decreased The Th17/trementioning

confidence: 99%

Silencing microRNA155 transforms the properties of endotoxin tolerant dendritic cells and enhance its therapeutic effect on sepsis murine model.

Hou

Yang

et al. 2020

Preprint

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Sepsis refers to the body's dysfunctional response to infection and leads to life-threatening organ dysfunction. Dentritic cells (DCs), a kind of powerful functional antigen-presenting cell, plays a critical role in immune response and has been used in the field of immunotherapy for multiple diseases. Endotoxin tolerance is a phenomenon that believed to prevent the organism from producing persistent and excessive inflammatory reaction and numerous studies indicated that endotoxin tolerant dendritic cells (ETDCs) have therapeutic effects on experimental models of several diseases. MicroRNA155(miR155), which plays a pivotal role in various physiological and pathological processes in immunity, was reported associated with the formation of endotoxin tolerance. In this paper, we explored the change of properties after silencing miR155 in ETDCs then attempted to study its effects on the murine model of sepsis. Endotoxin tolerant dendritic cells were transfected with adenovirus silencing miR155 and negative control adenovirus, thereafter collected for reverse transcription polymerase chain reaction of miR155, costimulatory molecules analysis, allogeneic mixed lymphocyte reaction and cytokine concentration evaluation. 42 balb/c mice were randomly divided into control group, sham operation group, sepsis group, ETDCs treatment group and miR155-/-ETDCs treatment group. Two treatment groups respectively received tail vein injection of ETDCs and miR155-/-ETDCs 24h earlier than cacal ligation puncture. Our results revealed that silencing miR155 could deepen the immature status of ETDCs and both ETDCs and miR155-/-ETDCs performed a protective effect in murine sepsis models while miR155-/-ETDCs got a better protection. We reasoned that miR155 participates the formation of endotoxin tolerance and the protective effects of ETDCs and miR155-/-ETDCs in the early stage of sepsis may achieved by altering the concentration of mouse cytokines to affect T cell differentiation and exert negative immune regulation.

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Th17/Regulatory T Cell Imbalance in Sepsis Patients with Multiple Organ Dysfunction Syndrome: Attenuated by High-volume Hemofiltration

Abstract: The level of Th17/Treg imbalance in sepsis is related to the occurrence and prognosis of MODS. High-volume hemofiltration can attenuate the Th17/Treg imbalance in sepsis patients, possibly by removing inflammatory mediators.

Cited by 38 publications

References 16 publications

T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics

T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics

Expression and significance of HMGB1 in patients with sepsis and effects on prognosis

Silencing microRNA155 transforms the properties of endotoxin tolerant dendritic cells and enhance its therapeutic effect on sepsis murine model.

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