Th17/Treg balance in children with obstructive sleep apnea syndrome and the relationship with allergic rhinitis

Ni, Kun; Zhao, Limin; Wu, Jiali; Chen, Wei; HongyaYang,; Li, Xiaoyan

doi:10.1016/j.ijporl.2015.06.026

Cited by 36 publications

(18 citation statements)

References 23 publications

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“…Moreover, the number of Th17 and Treg cells in the blood is an important index of AR [33]. In this study, we found an increase in the proportion of Th17 cells and a decrease in the proportion of Treg cells in AR rats, which is consistent with the result of a previous study [34]. However, this change could be reversed by MFXD, and this reversion is mainly a reduction in the number of Th17 cells.…”

Section: Journal Of Immunology Researchsupporting

confidence: 92%

Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance

Liang

Liu

Wei

et al. 2020

Journal of Immunology Research

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Mahuang Fuzi Xixin Decoction (MFXD), a Chinese traditional herbal formulation, has been used to treat allergic rhinitis (AR) in China for centuries. However, the mechanism underlying its effect on AR is unclear. This study investigated the mechanism underlying the therapeutic effects of MFXD on AR. Ovalbumin-induced AR rat models were established, which were then treated with MFXD for 14 days. Symptom scores of AR were calculated. The structure of the gut microbiota was analyzed by 16S rRNA gene sequencing and qPCR. Short-chain fatty acid (SCFA) content in rat stool and serum was determined by GC-MS. Inflammatory and immunological responses were assessed by histopathology, ELISA, flow cytometry, and western blotting. Our study demonstrated that MFXD reduced the symptom scores of AR and serum IgE and histamine levels. MFXD treatment restored the diversity of the gut microbiota: it increased the abundance of Firmicutes and Bacteroidetes and decreased the abundance of Proteobacteria and Cyanobacteria. MFXD treatment also increased SCFA content, including that of acetate, propionate, and butyrate. Additionally, MFXD administration downregulated the number of Th17 cells and the levels of the Th17-related cytokines IL-17 and RORγt. By contrast, there was an increase in the number of Treg cells and the levels of the Treg-related cytokines IL-10 and Foxp3. MFXD and butyrate increased the levels of ZO-1 in the colon. This study indicated MFXD exerts therapeutic effects against AR, possibly by regulating the gut microbial composition and Th17/Treg balance.

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Section: Journal Of Immunology Researchsupporting

confidence: 92%

Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance

Liang

Liu

Wei

et al. 2020

Journal of Immunology Research

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“…Moreover, recent studies have reported that the Th17/Treg ratio in peripheral blood is upregulated in children with OSA and AR to a greater extent than in children without AR, suggesting that AR could possibly promote the development of OSA. 27 Although the precise underlying pathophysiological mechanisms are not currently clear, it has been suggested that increased nasal resistance associated with AR and NAR, which results in negative pressure in the pharynx, predisposes the nose to additional upper airway collapse and exacerbates its effects during sleep because a subject is lying in a horizontal position. 25,[28][29][30] Similarly, Jiang and colleagues 31 have reported that patients with chronic rhinosinusitis who needed sinus surgery had a very high prevalence of OSA (64.7%), although there was no correlation with the severity of rhinosinusitis.…”

Section: Discussionmentioning

confidence: 99%

Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity

Zheng

Wang

et al. 2017

Journal of Clinical Sleep Medicine

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“…The literature has looked into the role of the immune system in managing adenoid hypertrophy and infection, and the modulation seen with disrupting of the lymphoid tissue. The role of Th17 and Treg has been examined, and a recent study showed that as the Th17/Treg ratio increased, the size of the adenoids increased, and the ratio was significantly higher in OSA patients compared to controls [83]. Surfactant proteins, epithelial proteins modulated in the inflammatory response, have also been studied.…”

Section: Genetics/immunologymentioning

confidence: 99%

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

Schüpper

Nation

Pransky

2018

Curr Otorhinolaryngol Rep

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Purpose of Review Review the current state of the adenoidectomy procedure in the pediatric population with up-to-date indications for surgery, operative techniques, adverse events, non-surgical management of adenoid hypertrophy, and future directions. Recent Findings Adenoidectomy is indicated in children for the treatment of sleep-disordered breathing, nasal airway obstruction, recurrent acute otitis media, and chronic rhinosinusitis. A new recommendation was released in 2016, not supporting adenoidectomy for a primary indication of otitis media in children under 4 years old, including those with prior tympanostomy tubes, unless a distinct indication exists such as nasal obstruction or chronic adenoiditis. Although adenotonsillectomy is the mainstay of treatment for obstructive sleep apnea (OSA), recent studies have identified that non-obese patients with moderate OSA and small tonsils have comparable benefits with adenoidectomy alone with less complications. While conventional approaches such as indirect mirror-assisted curette and suction coagulation are still utilized, direct transnasal endoscopeassisted removal of the adenoids has proven to be a safe technique, with good short-and long-term outcomes. Novel nonsurgical therapies including immunotherapy have been evaluated. Summary Adenoidectomy is a safe procedure in the pediatric population and leads to excellent outcomes. Adverse events are rare, and hospitalization is uncommon. Children with sleep disturbance from nasal airway obstruction, ear disease, or chronic rhinosinusitis are the best operative candidates for this procedure.

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Th17/Treg balance in children with obstructive sleep apnea syndrome and the relationship with allergic rhinitis

Cited by 36 publications

References 23 publications

Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance

Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance

Allergic and Non-Allergic Rhinitis Are Common in Obstructive Sleep Apnea but Not Associated With Disease Severity

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

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