Th17-type immunity and inflammation of aging

Merino, Kristen M.; Jazwinski, S. Michal; Rout, Namita

doi:10.18632/aging.203119

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…T cells and NK cells in circulation were functionally altered with age, expressing higher levels of genes associated with inflammation, cytotoxicity, and migration, reflecting previous findings in blood 67 . By contrast, T cells resident in tissues (such as the gut and lung) were impaired in their ability to produce pro-inflammatory cytokines such as IL-17, which is associated with reduced barrier immunity 68 , suggesting compromised in situ protection over age. These impaired tissue responses may result in reduced immune surveillance of an organ and predispose for tumor formation with age as observed for lung and colon cancer– diseases of the elderly 69 .…”

Section: Discussionmentioning

confidence: 99%

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Wells,

Rainbow,

Mark

et al. 2024

Preprint

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The immune system comprises multiple cell lineages and heterogeneous subsets found in blood and tissues throughout the body. While human immune responses differ between sites and over age, the underlying sources of variation remain unclear as most studies are limited to peripheral blood. Here, we took a systems approach to comprehensively profile RNA and surface protein expression of over 1.25 million immune cells isolated from blood, lymphoid organs, and mucosal tissues of 24 organ donors aged 20-75 years. We applied a multimodal classifier to annotate the major immune cell lineages (T cells, B cells, innate lymphoid cells, and myeloid cells) and their corresponding subsets across the body, leveraging probabilistic modeling to define bases for immune variations across donors, tissue, and age. We identified dominant tissue-specific effects on immune cell composition and function across lineages for lymphoid sites, intestines, and blood-rich tissues. Age-associated effects were intrinsic to both lineage and site as manifested by macrophages in mucosal sites, B cells in lymphoid organs, and T and NK cells in blood-rich sites. Our results reveal tissue-specific signatures of immune homeostasis throughout the body and across different ages. This information provides a basis for defining the transcriptional underpinnings of immune variation and potential associations with disease-associated immune pathologies across the human lifespan.

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Section: Discussionmentioning

confidence: 99%

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Wells,

Rainbow,

Mark

et al. 2024

Preprint

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“…CD161 is a C-type lectin receptor which is expressed in both T and NK cells (50). CD161+ T cells has been associated with IL-17 production and hence with pathogen clearance (51). In fact, we have previously observed that CD161+ CD8+ T cells were related with HIV and hepatitis C virus (HCV)-specific T cells polyfunctionality, which is essential for HIV spontaneous control and HCV spontaneous clearance (28).…”

Section: Discussionmentioning

confidence: 99%

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

Vitallé¹,

Pérez-Gómez²,

Ostos³

et al. 2022

JCI Insight

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The immune factors associated with impaired SARS-CoV-2 vaccine response in the elderly are mostly unknown. We studied >60 and <60 years old people vaccinated with SARS-CoV-2 BNT162b2 mRNA before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2 specific T cell response. The dramatic decrease in thymic function in aged people with >60 years of age, which fueled alteration in T cell homeostasis, and lower CD161+ T cell levels were associated with decreased T cell response two months after vaccination. Additionally, a deficient dendritic cell (DC) homing, activation and Toll like receptor (TLR)-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the >60 years old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.

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“…As reported above, inflammaging describes the chronic inflammation observed in the elderly and is partially linked to self-reactive T cells inducing chronic tissue damage and low-grade inflammation. Finally, an enhanced immune suppression is observed and linked to an expansion and accumulation of T-reg and Th17 cells in peripheral lymphoid organs with a relative increase in the production of IL-17 and IL-22 cytokines, which are important regulators of proinflammatory cytokines such as IL-6 and TNF-α ( 72 ). All those changes in T cell responses are linked to thymic involution, primarily observable during the adolescence phase and characterized by a progressive decline with lymphoid organs being substituted by adipose tissue ( 8 , 73 , 74 ).…”

Section: Aging Immunitymentioning

confidence: 99%

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

et al. 2023

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Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.

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Th17-type immunity and inflammation of aging

Cited by 11 publications

References 8 publications

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

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