Th2-dependent cytokine release in patients treated with coronary angioplasty

Abstract

A significant decrease was observed in Th2-dependent IL concentrations after PCI; increased Th2-dependent IL levels before PCI seem to correlate with the severity of coronary atherosclerosis.

A1 adenosine receptor deficiency or inhibition reduces atherosclerotic lesions in apolipoprotein E deficient mice

“…26 A correlation was present between the severity of the coronary lesions and serum IL-13 concentrations in patients with unstable angina treated with coronary angioplasty. 27 IL-13 treatment has been shown to damage endothelium, induces leucocyte attachment and infiltration through compliment-activated antibody-dependent cytotoxicity, and enhances atherosclerosis development in APOE-KO. 28 Previous study also demonstrates that IL-13 is strongly induced in adenosine deaminase-deficient mice.…”

Knockout of CD8 Delays Reendothelialization and Accelerates Neointima Formation in Injured Arteries of Mouse via TNF-α Inhibiting the Endothelial Cells Migration

“…T cell was regarded to play an important role in neointima formation after denudation injury [14], [15], [16], [17], but the role of CD8 in the reendothelialization and neointima formation was unclear. Firstly, the result of flow cytometry excluded the effect that CD8 deficiency may impact on CD4 + T cells after the femoral arterial wire injury in mice (Figure S4).…”

“…Accumulated evidences indicate that T cells are involved in neointima formation following arterial injury [14], [15], [16], [17], [18]. It was reported that, adoptive transfer of CD8 T cells but not CD4 T cells significantly attenuated the neointima formation in injured arteries of Rag1 −/− mice [19].…”

Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes

“…Although IL-4 is traditionally considered to be an anti-inflammatory cytokine, recent in vitro and in vivo studies have provided robust evidence that IL-4 exerts pro-inflammatory effects on vascular endothelium and may play a critical role in the development of atherosclerosis [51]. During percutaneous coronary intervention, the ratio of IL-4 levels before and after procedure was higher in patients with multivessel coronary artery disease than those with single-vessel coronary artery disease [52]. Whereas the combined effects of several cytokines may give synergistically detrimental results, the broad spectrum inhibition of cytokine production from T cells by MLB provides additional therapeutic benefits.…”