Th2 signals are not essential for the anti‐arthritic effects of <i>Trichinella spiralis</i> in mice

Osada, Yoshio; Morita, Kentaro; Tahara, Sayaka; Ishihara, Tsubasa; Wu, Zhiliang; Nagano, Isao; Maekawa, Yoichi; Nakae, Susumu; Sudo, Katsuko; Kanazawa, Tamotsu

doi:10.1111/pim.12677

Cited by 11 publications

(7 citation statements)

References 38 publications

(64 reference statements)

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“…We also observed significant impairment of anti‐IIC IgG production by Py infection (Figure 3). Taken together with the similar observation in helminth infections, 7,11 the impairment of humoral immunity in CIA may be a widely observed phenomenon among various parasites.…”

Section: Discussionsupporting

confidence: 60%

“…mansoni , 10 but did not abolish alleviation via T . spiralis 11 . Thus, Th2‐biased cytokine alteration is not always essential for the suppression of arthritis by helminths.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decade, our group has investigated the anti‐inflammatory effects of helminth infections on arthritis or T1D using Schistosoma mansoni , 7–10 Trichinella spiralis 11 and Heligmosomoides polygyrus 12 in experimental settings. In our studies, we found that Th2 cytokines are not essential for their anti‐disease effects in many cases.…”

Section: Introductionmentioning

confidence: 99%

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Non‐lethal rodent malarial infection prevents collagen‐induced arthritis in mice via anti‐arthritic immunomodulation

Gaballah

Morita

Shimizu

et al. 2021

Parasite Immunology

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Aims Immunomodulatory effects of parasitic infections on the outcomes of allergic or autoimmune disorders have been addressed in many experimental studies. We examined the effects of Plasmodium yoelii 17X NL (Py) infection on collagen‐induced arthritis (CIA). Methods and Results Male DBA/1J mice were immunized with bovine type II collagen (IIC). Py inoculation was induced at three different time points (1, 4 weeks after or 4 weeks before the immunization). Only the inoculation at 4 weeks after IIC immunization significantly inhibited arthritis development. Non‐malarial anaemia induced by phenylhydrazine hydrochloride (PHZ) did not affect arthritis development. In the infected mice, anti‐IIC IgG levels were transiently reduced. In addition, splenic production of pro‐arthritic cytokines (IL‐17 and TNF‐α) and IFN‐γ decreased, whereas IL‐10 production increased. Flow cytometric analysis clarified that the main IL‐10 producers in Py‐infected mice had the CD4+CD25–Foxp3– phenotype, presumably Tr1 cells. Conclusion We demonstrated that experimental malarial infection alleviated autoimmune arthritis via immunomodulation, suggesting the importance of malaria in the hygiene hypothesis and the significance of searching for therapeutic immunomodulatory molecules from malarial parasites.

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Section: Discussionsupporting

confidence: 60%

“…mansoni , 10 but did not abolish alleviation via T . spiralis 11 . Thus, Th2‐biased cytokine alteration is not always essential for the suppression of arthritis by helminths.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non‐lethal rodent malarial infection prevents collagen‐induced arthritis in mice via anti‐arthritic immunomodulation

Gaballah

Morita

Shimizu

et al. 2021

Parasite Immunology

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“…Indeed, it is well known that the major extrinsic driver of eosinophil expansion was helminth infection. Numerous previous studies in experimental mouse models have demonstrated clinical improvement of inflammatory activity in a variety of autoimmune and inflammatory diseases including RA (7,(62)(63)(64)(65)(66)(67). These observations led to the proposal that harness helminth and their secreted products would represent a promising interventional approach for the treatment of RA, as supported by the findings that a filarial nematode-derived glycoprotein, ES-62, has been proved to exert an anti-inflammatory and anti-osteoclastogenic effect in mouse arthritis models (68)(69)(70)(71).…”

Section: Future Perspective In Therapymentioning

confidence: 90%

Emerging Role of Eosinophils in Resolution of Arthritis

Qin

Jin

et al. 2021

Front. Immunol.

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Eosinophils are a minor component of circulating granulocytes, which are classically viewed as end-stage effector cells in host defense against helminth infection and promoting allergic responses. However, a growing body of evidence has emerged showing that eosinophils are versatile leukocytes acting as an orchestrator in the resolution of inflammation. Rheumatoid arthritis (RA) is the most common chronic inflammatory disease characterized by persistent synovitis that hardly resolves spontaneously. Noteworthy, a specific population of eosinophils, that is, regulatory eosinophils (rEos), was identified in the synovium of RA patients, especially in disease remission. Mechanistically, the rEos in the synovium display a unique pro-resolving signature that is distinct from their counterpart in the lung. Herein, we summarize the latest understanding of eosinophils and their emerging role in promoting the resolution of arthritis. This knowledge is crucial to the design of new approaches to rebalancing immune homeostasis in RA, considering that current therapies are centered on inhibiting pro-inflammatory cytokines and mediators rather than fostering the resolution of inflammation.

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“…Trichinella spiralis alleviated arthritis in CIA model through STAT6 independent mechanism (Osada et al, 2020).…”

Section: Autoimmune Diseases and Parasitic Infections: Rheumatoid Art...mentioning

confidence: 99%

Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases

Elsawey

Nabih

Gaballah

et al. 2022

Egyptian Academic Journal of Biological Sciences, E. Medical En

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The hygiene hypothesis has been implicated in the dramatic increase in autoimmune and allergic diseases noticed in recent decades, especially in developed countries. This growth was associated with lesser exposure to diverse immunoregulatory infectious agents. This hypothesis has been proved by many potent epidemiological and experimental studies. The results of these studies along with the analysis of the western world's microbiome helped us to have a greater idea about microorganisms shared in the hygiene hypothesis, as well as their main mechanisms that have an effect on the immune system. Protozoal infections have been proved to have remarkable immunomodulatory changes in different autoimmune diseases. Helminths and their derivatives were proved to have a protective role. Helminths' broad immunomodulatory effects have been tested in clinical trials of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and type-1 diabetes. In this review, we discussed particular parasitic infections and their immunomodulatory effects on some autoimmune diseases.

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Th2 signals are not essential for the anti‐arthritic effects of Trichinella spiralis in mice

Cited by 11 publications

References 38 publications

Non‐lethal rodent malarial infection prevents collagen‐induced arthritis in mice via anti‐arthritic immunomodulation

Non‐lethal rodent malarial infection prevents collagen‐induced arthritis in mice via anti‐arthritic immunomodulation

Emerging Role of Eosinophils in Resolution of Arthritis

Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases

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