Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy

Wang, Yufei; Yu, Hongdan; Li, Jing; Liu, Wenqiang; Yu, Sheng-xue; Lv, Pan; Zhao, Lipan; Wang, Xiaobai; Zuo, Zhili; Liu, Xuezheng

doi:10.1007/s00441-022-03689-8

Cited by 2 publications

(1 citation statement)

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“…88 IL-22Rα1 was previously described as a potentially important factor in pathogenesis of DR and fungal keratitis, but there is a lack of evidence on its role in glaucoma pathogenesis. 79,89,90 Our study shows the increased serum expression of IL-22Rα1, which is indirectly consistent with the research conducted by Zhao et al 91 The overexpression of IL22RA1 in human Tenon's capsule fibroblasts of individuals with glaucoma is related to intensified cell migration, proliferation, fibrosis, and autophagy, modulated by NR_003923 -long noncoding RNA (lncRNA). Summarized effects of increased activity of IL22RA1 and NR_003923 were associated with glaucoma progression.…”

Section: Il-22rα1supporting

confidence: 90%

Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis

Okruszko,

Szabłowski,

Zarzecki

et al. 2024

JIR

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Glaucoma is the most common optic neuropathy and the leading cause of irreversible blindness worldwide, which affects 3.54% of the population aged 40-80 years. Despite numerous published studies, some aspects of glaucoma pathogenesis, serum biomarkers, and their potential link with other diseases remain unclear. Recent articles have proposed that autoimmune, oxidative stress and inflammation may be involved in the pathogenesis of glaucoma. Methods: We investigated the serum expression of 92 inflammatory and neurotrophic factors in glaucoma patients. The study group consisted of 26 glaucoma patients and 192 healthy subjects based on digital fundography. Results: Patients with glaucoma had significantly lower serum expression of IL-2Rβ, TWEAK, CX3CL1, CD6, CD5, LAP TGF-beta1, LIF-R, TRAIL, NT-3, and CCL23 and significantly higher expression of IL-22Rα1. Conclusion:Our results indicate that patients with glaucoma tend to have lower levels of neuroprotective proteins and higher levels of neuroinflammatory proteins, similar to those observed in psychiatric, neurodegenerative and autoimmune diseases, indicating a potential link between these conditions and glaucoma pathogenesis.

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