2010
DOI: 10.1016/j.parint.2010.06.007
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Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway

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Cited by 20 publications
(13 citation statements)
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“…Acanthamoeba is capable of triggering the apoptosis of immune cells by activating caspase 3 . Indeed, the mere contact of cultured cells with Acanthamoeba and some of the soluble factors it releases was found to activate caspase 3 . Throughout the current study, likewise, cells positive to caspase 3 activity were evident in the stroma, even at 8 weeks post‐inoculation.…”
Section: Discussionsupporting
confidence: 56%
See 1 more Smart Citation
“…Acanthamoeba is capable of triggering the apoptosis of immune cells by activating caspase 3 . Indeed, the mere contact of cultured cells with Acanthamoeba and some of the soluble factors it releases was found to activate caspase 3 . Throughout the current study, likewise, cells positive to caspase 3 activity were evident in the stroma, even at 8 weeks post‐inoculation.…”
Section: Discussionsupporting
confidence: 56%
“…F, Eight weeks post-inoculation, it can see a diminished inflammatory process in corneal stroma, with scarce positive IL-8 positive cells (black arrow) was found to activate caspase 3. 35 Throughout the current study, likewise, cells positive to caspase 3 activity were evident in the stroma, even at 8 weeks post-inoculation. This can be explained by the need to clear the unnecessary vascularization and inflammatory cells generated at the early stages of amoebic infection.…”
Section: During the Development Of Ak Stemming From Inoculation Withsupporting
confidence: 59%
“…The initial binding leads to secondary events such as phagocytosis and toxin production resulting in the host cell death in a phosphotidylinositol 3-kinasedependent (PI3K) manner [ 63 ]. The downstream effectors of PI3K involves activation of proapoptotic molecules, Bak and Bax, loss of mitochondrial membrane potential and release of cytochrome c as well as caspase activation, all well-known mediators of the apoptosis [ 64 - 66 ]. Among host cell receptors, Toll-like receptor 4 (TLR4) showed involvement in Acanthamoeba recognition and exerting an effect through adaptor protein, Myeloid differentiation primary response 88 that led to the activation of transcription factors, nuclear factor-kappa B signalling through extracellular signal-regulated kinases (ERKs) inducing the secretion of cytokines including interleukin-8, tumor necrosis factor-alpha and interferon-beta in human corneal cells [ 67 ].…”
Section: Introductionmentioning
confidence: 99%
“…42 Current data regarding the distribution of various genotypes in Thailand are limited. Two previous studies have reported genotype T4 from multiple clinical cases and in pond water samples, 43,44 and genotype T5 has been reported from a soil sample, 45 but this is the first report to identify Acanthamoeba genotype T3 in contact lenses in Thailand. Despite few reports, T3 isolates of the pathogenic T3 genotype have been found in European countries.…”
Section: Discussionmentioning
confidence: 78%