The goal of the current study is to develop a diagnosis model for chili pepper disease diagnosis by applying filter and wrapper feature selection methods as well as a Multi-Layer Perceptron Neural Network (MLPNN). The data used for developing the model include 1) types, 2) causative agents, 3) areas of infection, 4) growth stages of infection, 5) conditions, 6) symptoms, and 7) 14 types of chili pepper diseases. These datasets were applied to the 3 feature selection techniques, including information gain, gain ratio, and wrapper. After selecting the key features, the selected datasets were utilized to develop the diagnosis model towards the application of MLPNN. According to the model’s effectiveness evaluation results, estimated by 10-fold cross-validation, it can be seen that the diagnosis model developed by applying the wrapper method along with MLPNN provided the highest level of effectiveness, with an accuracy of 98.91%, precision of 98.92%, and recall of 98.89%. The findings showed that the developed model is applicable.