Thalamic and Cerebellar Gray Matter Volume Reduction in Synthetic Cannabinoids Users

Nurmedov, Serdar; Metin, Barış; Ekmen, Sehadet; Noyan, Cemal Onur; Yılmaz, Onat; Darçın, Aslı Enez; Dılbaz, Nesrin

doi:10.1159/000430437

Cited by 36 publications

(22 citation statements)

References 15 publications

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“…Finally, we found that SUDs were associated with lower thalamic GM/WM across several substances including alcohol, cocaine, nicotine, methamphetamine, opioids and cannabis 55,56 . Reduced structural and functional integrity of the thalamus and its connectivity appear to be associated with the severity of SUD 57 .…”

Section: Primary Outcome: Altered Brain Morphometry In Sudsmentioning

confidence: 68%

Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis

Pando‐Naude

Toxto

Fernandez‐Lozano

et al. 2020

Preprint

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Substance use disorders (SUDs) are characterized by a compulsion to seek and consume one or more substances of abuse, with a perceived loss of control and negative emotional state. Repeated use of a substance results in synaptic and morphological changes, secondary to toxicity and SUD pathology in the dopamine striato-thalamo-cortical and limbic pathways. These neuroadaptations seem to vary between studies, which could be related to divergent effects of substances, consumption severity or other unknown factors. We therefore identified studies investigating the effects of SUDs using volumetric whole-brain voxel-based morphometry (VBM) in gray (GM) and white matter (WM). We performed a systematic review and meta-analysis of VBM studies using the anatomic likelihood estimation (ALE) method implemented in GingerALE (PROSPERO pre-registration CRD42017071222). Fifty studies met inclusion criteria and were included in the final quantitative meta-analysis, with a total of 538 foci, 88 experiments and 4370 participants. We found convergence and divergence in brain regions and volume effects (higher vs lower volume) in GM and WM depending on the severity of consumption pattern and type of substance. Convergent pathology was evident across substances in GM of the insula, anterior cingulate cortex, putamen, and thalamus, and in WM of the thalamic radiation and internal capsule bundle. Divergent pathology between occasional use (cortical pathology) and addiction (cortical-subcortical pathology) provides evidence of a possible top-down neuroadaptation. Our findings indicate distinctive brain morphometry alterations in SUDs, which may inform our understanding of disease progression and ultimately therapeutic approaches.MANUSCRIPT Pando-Naude, Victor Garza-Villarreal, Eduardo A.MANUSCRIPT Pando-Naude, Victor Garza-Villarreal, Eduardo A. 5 terms for articles published to the end of July 2018. No restrictions were placed on study design, but in order to be eligible for inclusion, the studies must have reported whole-brain VBM analyses. Screening and data extraction were performed using the Covidence tool 31 . The main outcome to extract was any change in gray and/or white matter analyzed using VBM, in stereotactic coordinates, comparing a substance user group and a healthy control group (details in Supplementary information). Quality assessment of MRI studies.Criteria for MRI quality reporting was selected from a set of guidelines for the standardized reporting of MRI studies [32][33][34] . Such guidelines dictate a more consistent and coherent policy for the reporting of MRI methods to ensure that methods can be understood and replicated. Analysis and meta-analytic technique.Statistically significant foci from between-group contrasts were extracted and recorded for each study. If necessary, coordinates were converted from Talairach coordinates to MNI space using the Lancaster transform (icbm2tal) incorporated in GingerALE (www.brainmap.org/). All metaanalyses were performed using anatomic likelihood estimation (ALE), implemented ...

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Section: Primary Outcome: Altered Brain Morphometry In Sudsmentioning

confidence: 68%

Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis

Pando‐Naude

Toxto

Fernandez‐Lozano

et al. 2020

Preprint

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“…SK'ların akut ve kronik dönemde psikomotor becerileri etkileyip etkilemediğini gösteren kontrollü çalışmalar henüz yeterli sayıda bulunmamaktadır. JWH-018, AM-2201, JWH-210, JWH-122 maruziyeti sonrası sürücülük becerilerinin ölçüldüğü bir çalışmada SK' kullanıcılarının sağlıklı kontrollere göre psikomotor becerilerinin daha düşük olduğu saptanmış olup, çalışmadaki örneklem sayısı sonuçların genellenebilirliği için oldukça düşüktür 27 Baş dönmesi 77 Kronik SSS'de yapısal ve işlevsel bozumlara ait bulgular 42,56 Hipokampus ve amigdalada yapısal ve işlevsel değişiklikler 53,54 saptanmıştır 28 . Sürücüler ile yapılan başka bir çalışmaya göre de bir SK türevi olan UR-144'ün esrara göre psikomotor becerileri ve sürücü performansını daha olumsuz etkilediği bildirilmiştir 29 .…”

Section: Psikomotor Becerilerunclassified

“…Bu çalışma SK kullanıcılarının bu alanda sıkıntı yaşadıklarını göstermektedir. Görsel ve işitsel seçici dikkatte gerekli olmayan arka plan uyaranlarını inhibe etmekte görevli talamusun gri cevherinde (CB1 reseptörlerince zengin) uzun süreli SK kullanıcılarında incelme tespit edilmiştir42 . SK kullanıcılarında, CB1 Arşiv Kaynak Tarama Dergisi .…”

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Sentetik Kannabinoidlerin Nöropsikiyatrik Etkileri

Aral

Avcı

Usta

2020

Arşiv Kaynak Tarama Dergisi

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Synthetic cannabinoids are common names of many compounds produced in a laboratory environment that mimic the psychoactive effects of cannabis. The use of synthetic cannabinoid is a public health problem that has become widespread among young people in recent years. Due to the increasing rate of usage, there are many studies needed to better understand the effects, reduce the consumption rate and facilitate the elimination of the negative effects it creates. Knowing the neuropsychiatric conditions that may occur as a result of the use of synthetic cannabinoids and distinguishing them from cannabis use will guide the arrangements to improve the functionality of the neurorehabilitation process.

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“…Furthermore, loss of gray matter volume has been described in the cerebellum of cocaine addicts (Sim et al, 2007;Moreno-Lopez et al, 2015), cannabis smokers (Battistella et al, 2014;Nurmedov et al, 2015), heroin addicts (Lin et al, 2012) and alcoholics (Durazzo et al, 2015;Sawyer et al, 2016), paralleling prior observations in the striato-cortico-limbic networks (Fein et al, 2002;Matochik et al, 2005;Kim et al, 2006;Sim et al, 2007).…”

Section: The Involvement Of the Cerebellum In Drug-induced Cue Reactimentioning

confidence: 56%

Involvement of the cerebellum in cocaine-induced memory

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PREFACEBecause of its role in drug-seeking, consumption and addictive behavior, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-induced memories. However, very few studies have focused on brain areas beyond the corticostriatal-limbic circuitry. Despite the growing evidence confirming the involvement of the cerebellum in drug-induced alterations, this structure has been traditionally disregarded in the addiction field Miquel et al, 2016).The general aim of the present research is to address wether the cerebellum is part of the neuronal systems that sustains the plasticity mechanisms underlying drug-induced conditioned memories. We have focused our research in an attempt to clarify if the cerebellum is involved in the acquisition and storage of drug memories. Although previous scattered reports described the involvement of the cerebellum in drug-related memories, this is the first attempt to address a detailed functional analysis about the issue.The present doctoral thesis contains three different chapters. The first two include two investigations that have been already published (Carbo-gas et al., 2014ab), and the third is one currently under revision. In the first chapter, Involving the cerebellum in cocaineinduced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine, we explored the pattern of neuronal activation as revealed by cFos immunoreactivity of mice trained to develop conditioned preference for an olfactory stimulus paired with cocaine. In the second one, entitled Cerebellar hallmarks of conditioned preference for cocaine, we used the same behavioral task of the first study in order to further extend the description of cFos expression patterns in cerebellar circuitry, including now the major inputs and one of the output nuclei of the cerebellum. 9In the last chapter, Cerebellar perineuronal nets in cocaine-induced Pavlovian memory:site does matter, we accomplished a broad analysis of perineuronal nets (PNNs) expression of cerebellar vermis. First, we analysed an outbred mouse strain trained to acquire preference for olfactory stimuli associated with cocaine. Second, α6Cre-Cacna1a mice were used to test if a reduction in the glutamate release of parallel fibres to Purkinje dendrites would alter the acquisition of cocainepreference conditioning and the expression of PNNs in the cerebellum.After the presentation of the chapters, there is a section where summarised findings, strengths and pitfalls as well as future directions are provided. References can be also found at the end of the present document.Finally, we conclude this thesis with an appendix. This document is formed by research not finished yet, but that may be of great relevance to understand the role of the cerebellum in addictive disorders. In that appendix, we explored the effect of a focal lesion in the dorsal cerebellar cortex (Lobule VIII) on the acquisition of food selfadministration. This researc...

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Thalamic and Cerebellar Gray Matter Volume Reduction in Synthetic Cannabinoids Users

Cited by 36 publications

References 15 publications

Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis

Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis

Sentetik Kannabinoidlerin Nöropsikiyatrik Etkileri

Involvement of the cerebellum in cocaine-induced memory

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