Thalamic Relay of Spontaneous Retinal Activity Prior to Vision

Mooney, Richard; Penn, Anna A.; Gallego, Roberto; Shatz, Carla J.

doi:10.1016/s0896-6273(00)80218-4

Cited by 204 publications

(172 citation statements)

References 40 publications

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“…As determined previously , neocortical recordings were performed from the region of maximal responsiveness to optic nerve (ON) stimulation of the V1 (0 -1.5 mm anterior to lambda suture and 2-3.5 mm from the midline) of P5-P6 rats using the experimental setup and conditions described previously (Leinekugel et al, 2002;Khazipov et al, 2004). Briefly, following the Guidelines of the Care and Use of Mammals in Neuroscience and Behavioral Research of the National Research council, the pups were anesthetized by hypothermia (ice-cooling anesthesia), known to preserve the anesthetic-sensitive retinal waves (Mooney et al, 1996). Under these conditions, the heads of the pups were fixed into the stereotaxic apparatus using two metal bars fixed with dental cement on the nasal and occipital bones, respectively.…”

Section: Methodsmentioning

confidence: 99%

Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual CortexIn Vivo

Hanganu¹,

Staiger²,

Ben-Ari³

et al. 2007

J. Neurosci.

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Acetylcholine (ACh) is known to shape the adult neocortical activity related to behavioral states and processing of sensory information. However, the impact of cholinergic input on the neonatal neuronal activity remains widely unknown. Early during development, the principal activity pattern in the primary visual (V1) cortex is the intermittent self-organized spindle burst oscillation that can be driven by the retinal waves. Here, we assessed the relationship between this early activity pattern and the cholinergic drive by either blocking or augmenting the cholinergic input and investigating the resultant effects on the activity of the rat visual cortex during the first postnatal week in vivo. Blockade of the muscarinic receptors by intracerebroventricular, intracortical, or supracortical atropine application decreased the occurrence of V1 spindle bursts by 50%, both the retina-independent and the optic nerve-mediated spindle bursts being affected. In contrast, blockade of acetylcholine esterase with physostigmine augmented the occurrence, amplitude, and duration of V1 spindle bursts. Whereas direct stimulation of the cholinergic basal forebrain nuclei increased the occurrence probability of V1 spindle bursts, their chronic immunotoxic lesion using 192 IgG-saporin decreased the occurrence of neonatal V1 oscillatory activity by 87%. Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli.

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Section: Methodsmentioning

confidence: 99%

Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual CortexIn Vivo

Hanganu¹,

Staiger²,

Ben-Ari³

et al. 2007

J. Neurosci.

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“…Hence, endogenous activity patterns have been replaced by an alternative, strikingly similar activity pattern-LGN neurons undergo periodic depolarizations highly correlated with neighboring cells (Mooney et al, 1996;Weliky and Katz, 1999). However, there are some important differences between the endogenous and induced patterns.…”

Section: Do Retinal Waves Play a Role In The Development Of Cortical mentioning

confidence: 99%

The role of nAChR‐mediated spontaneous retinal activity in visual system development

Feller

2002

J. Neurobiol.

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ABSTRACT:In the developing vertebrate retina, nAChR synapses are among the first to appear. This early cholinergic circuitry plays a key role in generating "retinal waves," spontaneously generated waves of action potentials that sweep across the ganglion cell layer. These retinal waves exist for a short period of time during development when several circuits within the visual system are being established. Here I review the cholinergic circuitry of the developing retina and the role these early circuits play in the development of the retina itself and of retinal projections to the lateral geniculate nucleus of the thalamus.

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“…Retinal waves are generated in the network of retinal ganglion and amacrine cells and synchronize most of retinal activity (Galli and Maffei, 1988;Meister et al, 1991;Wong et al, 1993;Torborg and Feller, 2005). Using an original in vitro preparation of the neonatal mouse intact retina and lateral geniculate nucleus (LGN), it was demonstrated that spontaneous retinal activity is transmitted via the optic nerve to the LGN, where it drives bursts of activity (Mooney et al, 1996). Modulation of retinal waves during the first postnatal week results in alteration of retinal projections to their subcortical targets, suggesting an instructive role for retinal waves in the development of retinogeniculate connectivity (Shatz and Stryker, 1988;Penn et al, 1998;Muir-Robinson et al, 2002;Stellwagen and Shatz, 2002;Grubb et al, 2003;McLaughlin et al, 2003;Chandrasekaran et al, 2005;Mrsic-Flogel et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Retinal Waves Trigger Spindle Bursts in the Neonatal Rat Visual Cortex

Hanganu

Ben-Ari

Khazipov

2006

Journal of Neuroscience

272

286

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During visual system development, the light-insensitive retina spontaneously generates waves of activity, which are transmitted to the lateral geniculate nucleus. The crucial question is whether retinal waves are further transmitted to the cortex and influence the early cortical patterns of activity. Using simultaneous recordings from the rat retina and visual cortex during the first postnatal week in vivo, we found that spontaneous retinal bursts are correlated with spindle bursts (intermittent network bursts associated with spindle-shape field oscillations) in the contralateral visual cortex (V1). V1 spindle bursts could be evoked by electrical stimulation of the optic nerve. Intraocular injection of forskolin, which augments retinal waves, increased the occurrence of V1 spindle bursts. Blocking propagation of retinal activity, or removal of the retina reduced the frequency, but did not completely eliminate the cortical spindle bursts. These results indicate that spontaneous retinal waves are transmitted to the visual cortex and trigger endogenous spindle bursts. We propose that the interaction between retinal waves and spindle bursts contributes to the development of visual pathways to the cortex.

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Thalamic Relay of Spontaneous Retinal Activity Prior to Vision

Cited by 204 publications

References 40 publications

Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual CortexIn Vivo

Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual CortexIn Vivo

The role of nAChR‐mediated spontaneous retinal activity in visual system development

Retinal Waves Trigger Spindle Bursts in the Neonatal Rat Visual Cortex

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